{"id":"W3022906021","doi":"10.1126/sciimmunol.aba6466","title":"A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain","year":2020,"lang":"en","type":"article","venue":"Science Immunology","topic":"Respiratory viral infections research","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Willow Biosciences (Canada)","funders":"Sanofi Genzyme","keywords":"Neutralization; Virology; Antibody; Epitope; Glycan; Virus; Biology; Neutralizing antibody; Microbiology; Glycoprotein; Immunology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087027,0.0001954074,0.0003609107,0.0005691373,0.0004670834,0.0001061708,0.0004488704,0.000113684,0.0002575057],"category_scores_gemma":[0.003307249,0.0001730684,0.00006579803,0.003213979,0.0007848428,0.0004326544,0.0003022467,0.0003200466,0.0006190512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983358,"about_ca_system_score_gemma":0.001267442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691437,"about_ca_topic_score_gemma":0.00004005162,"domain_scores_codex":[0.9971899,0.0004183368,0.0004738155,0.0006831318,0.000515464,0.0007193357],"domain_scores_gemma":[0.9983998,0.00008420149,0.0000950451,0.0005805337,0.0004522706,0.0003881589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00217237,0.0001253423,0.01744499,0.00002187695,0.00002089338,0.00009555146,0.0003701475,0.00001004837,0.9776365,0.00113704,0.0002190761,0.0007461378],"study_design_scores_gemma":[0.001604343,0.004030785,0.09030227,0.00004702173,0.00001262127,0.00004077996,0.0001746924,0.00009518661,0.890405,0.0001042426,0.01300115,0.0001819178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888466,0.0003204255,0.0005802262,0.008254777,0.0001336477,0.001370889,0.000006464179,0.0002085797,0.0002783765],"genre_scores_gemma":[0.9944415,0.000007004187,0.0005635479,0.004611671,0.00009877468,0.0001463239,0.000002099916,0.00002530665,0.0001037797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08723153,"threshold_uncertainty_score":0.7956856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06150807941154202,"score_gpt":0.3877465480694997,"score_spread":0.3262384686579576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}