{"id":"W3022920667","doi":"10.1002/eji.201948288","title":"Anti‐CD52 blocks EAE independent of PD‐1 signals and promotes repopulation dominated by double‐negative T cells and newly generated T and B cells","year":2020,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Li Ka Shing Foundation; Sanofi Genzyme; Sanofi","keywords":"CD52; Biology; Immunology; Repopulation; Immune system; Antibody; Multiple sclerosis; Molecular biology; Monoclonal antibody; Cell biology; Haematopoiesis; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028461,0.0005448955,0.0003618819,0.0003722688,0.0001237905,0.0002245788,0.0002441269,0.0003025119,0.001156838],"category_scores_gemma":[0.0001563557,0.00018943,0.0001683168,0.00009484043,0.0002348678,0.0001949836,0.0001428956,0.0007856502,0.0004188037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001724722,"about_ca_system_score_gemma":0.0001862078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003540512,"about_ca_topic_score_gemma":0.001138014,"domain_scores_codex":[0.9997382,0.00006070684,0.00002686768,0.00003093507,0.00004570225,0.00009776134],"domain_scores_gemma":[0.9998048,0.00003373493,0.00004906952,0.00002214472,0.00001353441,0.00007664233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004256772,0.0002171974,0.0001146596,0.00003913105,0.000006019346,0.00004240925,0.000009186629,0.00005939476,0.996753,0.00006343903,0.00004997231,0.002219852],"study_design_scores_gemma":[0.0002146862,0.004910919,0.006174102,0.0000199258,0.00003628309,0.0004546354,0.00002295137,0.001278459,0.9850831,0.00005637483,0.001742221,0.000006330367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959671,0.001507028,0.0008897569,0.00006229238,0.00003560827,0.00002791755,0.00009774953,0.00009248704,0.001320078],"genre_scores_gemma":[0.9964322,0.0007542992,0.000809578,0.00005169805,0.00002780793,0.00003386802,0.0002103663,0.00001794954,0.001662187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156838,"threshold_uncertainty_score":0.00387001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348624668983989,"score_gpt":0.2091103896620429,"score_spread":0.195624142972203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}