{"id":"W3023033208","doi":"10.1038/s41591-020-0858-8","title":"T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers","year":2020,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Research Resources; Yerkes National Primate Research Center, Emory University; U.S. Department of Health and Human Services; National Institutes of Health; International AIDS Vaccine Initiative; Emory University; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Neutralizing antibody; Heterologous; Virology; Immunology; Antibody; Biology; T cell; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292452,0.0002179079,0.0003176483,0.0001073403,0.0001477837,0.000008163017,0.0001308524,0.0003063309,0.0008227592],"category_scores_gemma":[0.00009425139,0.0001374524,0.0000489394,0.0003102966,0.00006565065,0.0001023201,0.00004379949,0.001058119,0.0003653062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005222837,"about_ca_system_score_gemma":0.00005834965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000191047,"about_ca_topic_score_gemma":0.00003250524,"domain_scores_codex":[0.9987946,0.0001298308,0.000201379,0.0003695438,0.0001055541,0.0003990761],"domain_scores_gemma":[0.9994885,0.00006780322,0.00008443605,0.0001932422,0.00006598231,0.0001000348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001267147,0.000271887,0.06467745,0.0001590699,0.0004616028,0.000363402,0.0009480306,0.00001339779,0.8859851,0.00004738271,0.04347349,0.002332066],"study_design_scores_gemma":[0.0425764,0.01528077,0.3927177,0.001384122,0.0008752725,0.0005862996,0.0004649495,0.00005521679,0.3115363,0.00005178073,0.2332961,0.001175116],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850714,0.004152924,0.0001679153,0.007376107,0.0005504998,0.0004024073,0.0000164668,0.0001057316,0.002156547],"genre_scores_gemma":[0.9971076,0.0001941925,0.0000433136,0.0008952898,0.0002303027,0.00001283544,0.000567186,0.00002398083,0.0009252725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5744488,"threshold_uncertainty_score":0.9008637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00973890748521071,"score_gpt":0.2812829037712646,"score_spread":0.2715439962860539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}