{"id":"W3023033208","doi":"10.1038/s41591-020-0858-8","title":"T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers","year":2020,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Research Resources; Yerkes National Primate Research Center, Emory University; U.S. Department of Health and Human Services; National Institutes of Health; International AIDS Vaccine Initiative; Emory University; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Neutralizing antibody; Heterologous; Virology; Immunology; Antibody; Biology; T cell; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000211223,0.0003058786,0.0003322167,0.0001568701,0.0000963036,0.0002451158,0.0001797678,0.0003892631,0.001149373],"category_scores_gemma":[0.0001967647,0.0001078935,0.0001736918,0.00006779042,0.0002033071,0.0001562779,0.0001291716,0.0008491643,0.0003190536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171235,"about_ca_system_score_gemma":0.000222347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006337122,"about_ca_topic_score_gemma":0.001105387,"domain_scores_codex":[0.9998292,0.00002900614,0.00001222938,0.0000255787,0.00003661248,0.00006737566],"domain_scores_gemma":[0.9998486,0.00004898134,0.00002624511,0.00002375099,0.00002123678,0.00003118418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001604254,0.0001658586,0.0002449487,0.00003550161,0.00000550087,0.0000240871,0.00001440494,0.0001085835,0.9968626,0.00006270904,0.00006016825,0.002255202],"study_design_scores_gemma":[0.0000620428,0.005340493,0.004135489,0.00001665983,0.00002734838,0.0002941995,0.00003658229,0.001499188,0.9862255,0.00009926323,0.002258765,0.000004475294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967848,0.0004893909,0.001501426,0.00008895914,0.00004592756,0.00003898171,0.00008565787,0.00007034436,0.0008945649],"genre_scores_gemma":[0.9965617,0.0002382963,0.00130552,0.00008179834,0.00002299077,0.00003022135,0.0001990571,0.00001274973,0.001547551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149373,"threshold_uncertainty_score":0.003845096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00973890748521071,"score_gpt":0.2812829037712646,"score_spread":0.2715439962860539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}