{"id":"W3023067543","doi":"10.1136/gutjnl-2019-319912","title":"Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression","year":2020,"lang":"en","type":"article","venue":"Gut","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Cancer Institute; National Institutes of Health; Deutsche Forschungsgemeinschaft; Mitsukoshi Health and Welfare Foundation; Uehara Memorial Foundation; Pancreatic Cancer Action Network; Lustgarten Foundation; Japan Society for the Promotion of Science; American Association for Cancer Research","keywords":"Pancreatic cancer; Immune system; Ductal cells; Pancreatic Intraepithelial Neoplasia; Cancer research; Lymphocyte; Pancreatitis; Biology; Carcinogenesis; Adenocarcinoma; Adoptive cell transfer; Pancreas; Immunology; Medicine; T cell; Internal medicine; Endocrinology; Cancer; Pancreatic ductal adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822849,0.0005476411,0.0002550495,0.0003077674,0.0001217314,0.0004065681,0.0001402701,0.0002297136,0.00171957],"category_scores_gemma":[0.0001108794,0.0001490603,0.0003460617,0.0001753051,0.0002210388,0.0002388911,0.0002874747,0.0007987581,0.0005605497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001517114,"about_ca_system_score_gemma":0.0001171046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009034783,"about_ca_topic_score_gemma":0.0001164138,"domain_scores_codex":[0.999783,0.00004330069,0.00002504093,0.00004751815,0.00003753636,0.00006369282],"domain_scores_gemma":[0.9998181,0.00002012097,0.00007794955,0.00002120432,0.00001314333,0.00004947872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003521531,0.0001189333,0.0009763318,0.0001404387,0.000009092795,0.0001825907,0.00002774253,0.00004283889,0.9955575,0.00007397034,0.00007767425,0.002440705],"study_design_scores_gemma":[0.0003764845,0.003807493,0.06666204,0.0001285072,0.0001043023,0.004130438,0.0002617285,0.00150428,0.9105351,0.0002915379,0.01218122,0.00001685894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992196,0.003938887,0.001614439,0.0001470339,0.00004100391,0.00004199162,0.0003088266,0.0001209938,0.001590862],"genre_scores_gemma":[0.9938239,0.002792658,0.001045112,0.0001006918,0.00004058329,0.00008008523,0.0003451,0.00001973033,0.001752118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171957,"threshold_uncertainty_score":0.005752504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02094261735264381,"score_gpt":0.2512323343258355,"score_spread":0.2302897169731917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}