{"id":"W3023069627","doi":"10.1200/jco.2015.33.3_suppl.646","title":"Genomic markers of panitumumab resistance including ERBB2/HER2 in a phase II study of <i>KRAS</i> wild-type (wt) metastatic colorectal cancer (mCRC).","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"KRAS; Panitumumab; Colorectal cancer; Medicine; Cancer research; Cancer; Mutation; Point mutation; Primary tumor; Oncology; Internal medicine; Gene; Biology; Genetics; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008068344,0.0005809861,0.0007404125,0.0002580952,0.0002276696,0.0005107832,0.0002298008,0.000448964,0.0009453163],"category_scores_gemma":[0.0004240304,0.0003775693,0.0004021724,0.0002329157,0.0003903133,0.0001984228,0.000127809,0.0008606694,0.0002015186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005804963,"about_ca_system_score_gemma":0.0005211004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006303879,"about_ca_topic_score_gemma":0.001428208,"domain_scores_codex":[0.9998022,0.00007050188,0.000009003427,0.0000535033,0.00003117321,0.000033607],"domain_scores_gemma":[0.999685,0.00005686089,0.00007960323,0.00002224518,0.00002391201,0.0001323332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1964741,0.03244715,0.1993137,0.0005060823,0.001147635,0.001390975,0.0005279199,0.00278446,0.5049393,0.0001462879,0.001647352,0.05867496],"study_design_scores_gemma":[0.04974695,0.3351381,0.5564528,0.00002779522,0.001349634,0.004365386,0.0002056782,0.004611405,0.04415534,0.0001603488,0.003723103,0.00006345163],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992368,0.0001951176,0.00009942272,0.00004191031,0.000005556974,0.0001244097,0.0001561669,0.000007076744,0.0001333539],"genre_scores_gemma":[0.99805,0.0001668157,0.0004624676,0.0001059734,0.00001187547,0.0001182725,0.0007262577,0.000007213897,0.0003510505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009453163,"threshold_uncertainty_score":0.004267037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2035073904796449,"score_gpt":0.500983627970606,"score_spread":0.2974762374909611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}