{"id":"W3023084813","doi":"10.3389/fped.2020.00197","title":"Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea","year":2020,"lang":"en","type":"article","venue":"Frontiers in Pediatrics","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia; BC Cancer Agency; BC Children's Hospital; Prevention of Organ Failure","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medical Research Charities Group","keywords":"Immunogenicity; Medicine; Immunology; Vaccination; Cohort; Hepatitis B; Cord blood; Immune system; Virology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02408431,0.002158327,0.001823101,0.002071883,0.003294002,0.002105606,0.002840236,0.002868821,0.09197522],"category_scores_gemma":[0.02890352,0.001279779,0.001727958,0.001944586,0.0009937098,0.001647472,0.002256767,0.002580004,0.01912884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003309914,"about_ca_system_score_gemma":0.01531147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005940202,"about_ca_topic_score_gemma":0.008660354,"domain_scores_codex":[0.9899355,0.006010002,0.001548081,0.001062579,0.0007638794,0.0006800144],"domain_scores_gemma":[0.9814236,0.003089087,0.002135005,0.003950179,0.007344583,0.0020575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.07133765,0.008930524,0.03979355,0.02150684,0.00134806,0.002664717,0.002687949,0.004492945,0.006729992,0.02483898,0.5400118,0.275657],"study_design_scores_gemma":[0.05779193,0.01890803,0.127828,0.01971343,0.000741708,0.001148222,0.002512113,0.005638395,0.004514374,0.01534685,0.7454165,0.0004405494],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006419127,0.0003881027,0.01079868,0.001317864,0.0009759021,0.9357483,0.03517595,0.000379858,0.008796293],"genre_scores_gemma":[0.004389899,0.0001808996,0.009018628,0.0004543047,0.00008353715,0.9792907,0.00457628,0.00002246021,0.001983226],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09197522,"threshold_uncertainty_score":0.3076878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04767313077892349,"score_gpt":0.3818694873078233,"score_spread":0.3341963565288998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}