{"id":"W3023156490","doi":"10.1074/jbc.ra119.012425","title":"Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"AKT1; Phosphorylation; Kinase; Biology; Signal transduction; Cell biology; Chemistry; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004548756,0.0004816169,0.0003856643,0.0003674256,0.0003122304,0.0005967052,0.0002036546,0.0001692096,0.004699655],"category_scores_gemma":[0.0002628561,0.0001752599,0.0004076164,0.0004080513,0.0002832912,0.0003029905,0.0002228757,0.0007470492,0.001038898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004583553,"about_ca_system_score_gemma":0.0004559435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006512366,"about_ca_topic_score_gemma":0.001257644,"domain_scores_codex":[0.9995438,0.00007935339,0.00004178911,0.0001416431,0.00011007,0.0000832236],"domain_scores_gemma":[0.9998717,0.00002812636,0.00003591082,0.0000178815,0.00001999293,0.00002635169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002913859,0.00007286268,0.001266243,0.0001016229,0.00002663777,0.00003532103,0.0000138914,0.0003741791,0.991601,0.0002055703,0.0002844878,0.005726863],"study_design_scores_gemma":[0.00002027826,0.0001901625,0.004715146,0.000004440697,0.0000360868,0.0002299692,0.00001233288,0.002043234,0.9892346,0.00009289949,0.003408997,0.00001201889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824725,0.002338931,0.007075967,0.00026779,0.0001407017,0.00005869571,0.00219048,0.0002282871,0.005226697],"genre_scores_gemma":[0.9900595,0.001168309,0.005101074,0.0001572233,0.00001603682,0.00005076548,0.001696611,0.00005835698,0.00169202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004699655,"threshold_uncertainty_score":0.01572186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423414768848885,"score_gpt":0.2531681302953129,"score_spread":0.2289339826068241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}