{"id":"W3023193177","doi":"10.1038/s41598-020-64335-3","title":"Minimally Invasive Cell-Free Human Embryo Aneuploidy Testing (miPGT-A) Utilizing Combined Spent Embryo Culture Medium and Blastocoel Fluid –Towards Development of a Clinical Assay","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; CReATe Fertility Centre","funders":"","keywords":"Blastocoel; Embryo; Aneuploidy; Andrology; Embryogenesis; Medicine; Pathology; Biology; Cell biology; Blastocyst; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004270809,0.0006625001,0.0008470979,0.001410622,0.0002446798,0.001192318,0.0008280886,0.0008676718,0.0007604738],"category_scores_gemma":[0.005738718,0.0004510148,0.0004294534,0.000573618,0.0008794801,0.0006901957,0.001333597,0.0009734203,0.0005466851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230788,"about_ca_system_score_gemma":0.0004046745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004514107,"about_ca_topic_score_gemma":0.0009725264,"domain_scores_codex":[0.9930084,0.002070302,0.0004448574,0.001302048,0.003016406,0.0001580271],"domain_scores_gemma":[0.9958131,0.001949625,0.0009811295,0.0006008172,0.0004433318,0.0002119289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004215094,0.00009268407,0.03418036,0.0002387077,0.0001020058,0.0003711123,0.00020443,0.0004647478,0.9230496,0.0002126027,0.0001238378,0.04053834],"study_design_scores_gemma":[0.00003512829,0.003551987,0.1147087,0.0001089576,0.0002461505,0.009129451,0.000193442,0.01002352,0.8576065,0.0003402837,0.003947541,0.0001082727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7274687,0.009509562,0.2580782,0.0002882763,0.0001164218,0.0006055221,0.0004879261,0.0008793364,0.002565986],"genre_scores_gemma":[0.7769493,0.002945584,0.2168861,0.000232276,0.00006290798,0.0002998875,0.0008410074,0.0001061891,0.001676782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004270809,"threshold_uncertainty_score":0.02258646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07547841600565261,"score_gpt":0.3229503734215064,"score_spread":0.2474719574158538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}