{"id":"W3023193177","doi":"10.1038/s41598-020-64335-3","title":"Minimally Invasive Cell-Free Human Embryo Aneuploidy Testing (miPGT-A) Utilizing Combined Spent Embryo Culture Medium and Blastocoel Fluid –Towards Development of a Clinical Assay","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; CReATe Fertility Centre","funders":"","keywords":"Blastocoel; Embryo; Aneuploidy; Andrology; Embryogenesis; Medicine; Pathology; Biology; Cell biology; Blastocyst; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002817863,0.0003259477,0.0008238435,0.0001277069,0.0003904379,0.0001303949,0.0002905216,0.0002134793,0.00004815225],"category_scores_gemma":[0.01205415,0.0002734745,0.0001626857,0.0005884221,0.0005154256,0.000131837,0.0007004867,0.0004532998,0.00001224468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004537491,"about_ca_system_score_gemma":0.001323081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002540889,"about_ca_topic_score_gemma":0.00003428679,"domain_scores_codex":[0.9951611,0.0001166915,0.001861576,0.001178763,0.001207121,0.0004747515],"domain_scores_gemma":[0.9964374,0.0003849531,0.0008967401,0.0008514396,0.0006005672,0.0008289455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002985306,0.0008234675,0.1354497,0.001070416,0.0002300242,0.005055015,0.005469368,0.00001469642,0.8087177,0.00002652389,0.03802845,0.004816141],"study_design_scores_gemma":[0.006124167,0.002688113,0.3037896,0.002100172,0.0007807665,0.0009352357,0.002643923,0.00115885,0.6706688,0.0006116045,0.007429621,0.00106915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897448,0.0002299222,0.0001156268,0.0005349932,0.001301633,0.0008625873,0.00001106396,0.0001497903,0.007049538],"genre_scores_gemma":[0.9732073,0.000006386614,0.02533176,0.000224188,0.0001940283,0.00002505775,0.0001597273,0.00003549592,0.0008160857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1683399,"threshold_uncertainty_score":0.9999717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07547841600565261,"score_gpt":0.3229503734215064,"score_spread":0.2474719574158538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}