{"id":"W3023240913","doi":"10.1182/blood.2019004334","title":"A hemophilia A mouse model for the in vivo assessment of emicizumab function","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de la Recherche; Ottawa Hospital Research Institute","keywords":"In vivo; Thromboplastin; Partial thromboplastin time; Bleeding diathesis; Chemistry; Internal medicine; Coagulation; Medicine; Immunology; Endocrinology; Platelet; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000823405,0.00216086,0.0007809648,0.001919382,0.0005439685,0.0007781149,0.0008553879,0.00202309,0.004833426],"category_scores_gemma":[0.0002078896,0.0006322465,0.0008387395,0.0006666893,0.0005822307,0.0007980677,0.0003597061,0.004107335,0.001665272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006389602,"about_ca_system_score_gemma":0.0003197835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000611356,"about_ca_topic_score_gemma":0.0009170413,"domain_scores_codex":[0.9990366,0.0001572499,0.0001415974,0.0002854713,0.0002274405,0.000151734],"domain_scores_gemma":[0.9994293,0.00008335346,0.0001653474,0.00009135826,0.00006831744,0.0001623763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004309904,0.0005188706,0.0001566745,0.00007611888,0.00002594885,0.0001211796,0.0000429149,0.0001713747,0.995827,0.0006482012,0.000334868,0.001645756],"study_design_scores_gemma":[0.0002716016,0.002608639,0.002317274,0.00004344876,0.000107649,0.0009080146,0.00003624773,0.004465843,0.9799702,0.000308527,0.008936925,0.00002578077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8876795,0.00624243,0.07738215,0.001260902,0.0006447146,0.001337588,0.01002812,0.002993398,0.01243114],"genre_scores_gemma":[0.897976,0.004932741,0.05540333,0.0006466184,0.0001830739,0.002328411,0.008724206,0.0005411212,0.02926456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004833426,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05238573724199593,"score_gpt":0.3280100880371267,"score_spread":0.2756243507951308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}