{"id":"W3023250971","doi":"10.1080/19490976.2020.1755413","title":"Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes","year":2020,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; National Natural Science Foundation of China; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute","keywords":"Biology; Microbiome; Verrucomicrobia; Akkermansia; Firmicutes; Butyrate; Proteobacteria; Bacteroidetes; Berberine; Halomonas; Biochemistry; Bacteroides; Bacteria; Genetics; Fermentation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007138189,0.0002131681,0.0004010355,0.0001454326,0.00007642774,0.00002966786,0.0001060999,0.00008700153,0.0002123765],"category_scores_gemma":[0.00009927346,0.0001689072,0.00008746812,0.000180182,0.00009606875,0.00007121463,0.0002105399,0.0002701066,0.00002508635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001978472,"about_ca_system_score_gemma":0.00005055702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001697167,"about_ca_topic_score_gemma":0.000004025709,"domain_scores_codex":[0.998819,0.00003900413,0.0002454018,0.0003400386,0.0002576826,0.0002988986],"domain_scores_gemma":[0.9994305,0.0001010494,0.00006307533,0.0001311134,0.00008792862,0.0001863216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003213392,0.00005629235,0.01066608,0.0008785734,0.0001818858,0.00003887694,0.000462016,0.00000225645,0.9762859,0.00005685605,0.002199171,0.008850783],"study_design_scores_gemma":[0.003358139,0.001298042,0.2666586,0.0002217778,0.00008861631,0.0001051666,0.0001298818,0.0001446594,0.7258015,0.00001627445,0.001980087,0.000197264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963479,0.00105624,0.000009678679,0.001764823,0.00006477655,0.0004245342,0.0001116645,0.0000413771,0.0001789982],"genre_scores_gemma":[0.9980442,0.00006151968,0.0003592706,0.0005357271,0.0003040949,0.00001344408,0.0001698273,0.0000275613,0.0004843668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2559925,"threshold_uncertainty_score":0.6887835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0310125831210675,"score_gpt":0.2797945106806984,"score_spread":0.2487819275596309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}