{"id":"W3023250971","doi":"10.1080/19490976.2020.1755413","title":"Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes","year":2020,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; National Natural Science Foundation of China; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute","keywords":"Biology; Microbiome; Verrucomicrobia; Akkermansia; Firmicutes; Butyrate; Proteobacteria; Bacteroidetes; Berberine; Halomonas; Biochemistry; Bacteroides; Bacteria; Genetics; Fermentation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408942,0.0002578338,0.0002613874,0.0001990009,0.0001425501,0.0002489881,0.0000822048,0.0003038351,0.001995138],"category_scores_gemma":[0.0002648311,0.0001085124,0.0001884523,0.0001696793,0.0002000665,0.0003239602,0.0001494189,0.0004656352,0.0002531165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001218366,"about_ca_system_score_gemma":0.000129651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002895358,"about_ca_topic_score_gemma":0.000646694,"domain_scores_codex":[0.9998671,0.00003330807,0.00001015288,0.000038192,0.00002730636,0.00002397612],"domain_scores_gemma":[0.9998705,0.00003614107,0.00003376672,0.00001544681,0.00001935658,0.00002485243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008407653,0.00004725491,0.0005409435,0.00011046,0.00001624192,0.00002479029,0.00002392829,0.00005859382,0.9946322,0.00006050321,0.00005304461,0.003591313],"study_design_scores_gemma":[0.00007437451,0.004413945,0.03128695,0.00003656119,0.0000975233,0.0003148538,0.0001846175,0.0005653851,0.9564316,0.0002765531,0.006294563,0.00002318012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914064,0.003341435,0.001302009,0.0001283498,0.00006577652,0.0000360328,0.0009015023,0.00005245746,0.00276586],"genre_scores_gemma":[0.9932017,0.001240247,0.002437812,0.0001791335,0.00001501927,0.00003998884,0.0006850319,0.00001785596,0.00218318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001995138,"threshold_uncertainty_score":0.006674409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0310125831210675,"score_gpt":0.2797945106806984,"score_spread":0.2487819275596309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}