{"id":"W3023268851","doi":"10.1016/j.neuroscience.2020.04.041","title":"Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing","year":2020,"lang":"en","type":"article","venue":"Neuroscience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Biology; Neuroscience; Cell type; Motor neuron; Population; Cell; Phenotype; Human brain; Spinal column; Progenitor cell; Computational biology; Embryonic stem cell; Cell biology; Genetics; Stem cell; Gene; Medicine; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004918548,0.0003660277,0.0003509294,0.0005289511,0.0002270185,0.000445725,0.0002812535,0.0002694501,0.0007869453],"category_scores_gemma":[0.0007389484,0.0001466904,0.0003125354,0.0003142048,0.0001997489,0.0001605082,0.0001664476,0.0004566588,0.0009577249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684615,"about_ca_system_score_gemma":0.0004689175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007712462,"about_ca_topic_score_gemma":0.001249096,"domain_scores_codex":[0.999742,0.00002751281,0.00005099913,0.00005114959,0.0001050775,0.0000232147],"domain_scores_gemma":[0.9996499,0.0001003803,0.00004962481,0.00004780635,0.0001322498,0.00002005888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002117974,0.00001453832,0.0003425527,0.00004939332,0.000006929891,0.0000660089,0.0000300377,0.0004835907,0.9938307,0.0001501787,0.00006898113,0.004935975],"study_design_scores_gemma":[0.000009516344,0.0001088211,0.005276553,0.00002668899,0.00004744244,0.0002985247,0.00005212849,0.004846012,0.9807521,0.0002719597,0.008297564,0.00001265676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6047486,0.002725342,0.3608516,0.0002795926,0.0001426961,0.001474404,0.01961409,0.001163679,0.009000017],"genre_scores_gemma":[0.6211634,0.005109312,0.3252954,0.0004184422,0.00005495717,0.001636152,0.03992246,0.000688798,0.005711022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007869453,"threshold_uncertainty_score":0.002632618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04261893261404929,"score_gpt":0.2681102115038808,"score_spread":0.2254912788898315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}