{"id":"W3023310607","doi":"10.3390/cells9051131","title":"Lysosomal Biology and Function: Modern View of Cellular Debris Bin","year":2020,"lang":"en","type":"review","venue":"Cells","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Diabetes Canada","keywords":"Lysosome; Cell biology; Endosome; Exocytosis; Autophagy; Biology; Endocytosis; ESCRT; Function (biology); Mannose 6-phosphate receptor; Intracellular; Cell; Biochemistry; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004105737,0.0008069286,0.001022301,0.001994535,0.0004071353,0.001666464,0.0007921997,0.001463426,0.003560373],"category_scores_gemma":[0.0004721603,0.000235037,0.0004278757,0.001956713,0.001095187,0.002563486,0.001021275,0.002343161,0.002404671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001199398,"about_ca_system_score_gemma":0.001554635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063941,"about_ca_topic_score_gemma":0.001110693,"domain_scores_codex":[0.9998114,0.00003076915,0.00002163089,0.00003614903,0.00007914771,0.0000210875],"domain_scores_gemma":[0.9998102,0.00006950346,0.00002017784,0.00001133514,0.00006040466,0.00002850361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001392956,0.00005593305,0.000208014,0.01558834,0.00009474096,0.0004617301,0.00022476,0.0003947323,0.005628738,0.03406105,0.06940841,0.8737342],"study_design_scores_gemma":[0.000004187775,0.00003710112,0.000260468,0.001157357,0.00002424125,0.0008624859,0.00005016221,0.00004237263,0.0004553611,0.005174353,0.9919228,0.000009128242],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007882823,0.9972668,0.0002301363,0.0005401351,0.0004013151,0.000002270377,0.00001288846,0.000006708212,0.001460999],"genre_scores_gemma":[0.0008501277,0.9969717,0.0001908281,0.0004107661,0.0003753235,0.000004416954,0.00002791635,0.000001954495,0.001166924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003560373,"threshold_uncertainty_score":0.01191062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179245934005784,"score_gpt":0.2739254473963605,"score_spread":0.2521329880563027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}