{"id":"W3023310607","doi":"10.3390/cells9051131","title":"Lysosomal Biology and Function: Modern View of Cellular Debris Bin","year":2020,"lang":"en","type":"review","venue":"Cells","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Diabetes Canada","keywords":"Lysosome; Cell biology; Endosome; Exocytosis; Autophagy; Biology; Endocytosis; ESCRT; Function (biology); Mannose 6-phosphate receptor; Intracellular; Cell; Biochemistry; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001293075,0.0003235723,0.001094118,0.0000579313,0.00003598485,0.00001291576,0.0001945092,0.0004395013,0.00004582935],"category_scores_gemma":[0.00001665659,0.0002748487,0.0003887227,0.0001163347,0.0001157953,0.000001222746,0.0001812857,0.0001706308,0.00003638743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005231068,"about_ca_system_score_gemma":0.0001081913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009030551,"about_ca_topic_score_gemma":8.656393e-7,"domain_scores_codex":[0.9985984,0.000165118,0.0004346709,0.0005330089,0.00006877018,0.0002000255],"domain_scores_gemma":[0.9992286,0.00002408465,0.0002321759,0.000357579,0.00004390624,0.0001136457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001521423,0.00002631195,0.000001697907,0.003793044,0.0002209247,0.000005113716,0.00001161568,6.800765e-7,0.1166173,0.00007574201,0.0008933395,0.878339],"study_design_scores_gemma":[0.0001551744,0.0001465595,3.683399e-7,0.000407645,0.0005631727,0.00001280734,0.000002423565,0.000008345737,0.01412654,0.00007088631,0.9842488,0.0002572774],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002523107,0.9966692,0.002046504,0.00000959753,0.0003866842,0.000232344,0.00008945212,0.00001200612,0.0003019458],"genre_scores_gemma":[0.0008833773,0.9976817,0.0001653184,0.00006858695,0.0005582865,0.00001561153,0.0002801205,0.00005255065,0.0002943863],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9833555,"threshold_uncertainty_score":0.9999704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179245934005784,"score_gpt":0.2739254473963605,"score_spread":0.2521329880563027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}