{"id":"W3023317226","doi":"10.1158/1557-3125.ras18-ia09","title":"Abstract IA09: Targeting K-RAS4B on biologic membranes","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Prenylation; Signal transduction; Cell biology; Cancer; Membrane; Kinase; Mutant; Chemistry; Biology; Cancer research; Biochemistry; Gene; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001505156,0.0003372621,0.0002834315,0.0001885393,0.0002361275,0.0004347981,0.0003967077,0.0006309057,0.002614817],"category_scores_gemma":[0.0001724043,0.0001592956,0.0004267821,0.0001455751,0.0001778696,0.0002840585,0.0004558279,0.0009340998,0.001830964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006286126,"about_ca_system_score_gemma":0.0002512304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008558876,"about_ca_topic_score_gemma":0.0005152684,"domain_scores_codex":[0.9998544,0.00001867381,0.00001069675,0.0000299014,0.00005117076,0.00003515014],"domain_scores_gemma":[0.9999447,0.000004969996,0.00001204067,0.000005783359,0.00001285147,0.0000196114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001202136,0.00004118557,0.00007253892,0.00009123243,0.00001073073,0.00006959991,0.00001543728,0.0001755513,0.9953048,0.0004122976,0.0005700589,0.003116417],"study_design_scores_gemma":[0.00001949172,0.0002086926,0.0004122517,0.00001643521,0.00002054323,0.0002204453,0.00002523982,0.00169186,0.9843539,0.00007564112,0.01294633,0.00000918404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503659,0.01308493,0.01465279,0.00169626,0.0006208396,0.0001865413,0.001064059,0.0008075378,0.01752109],"genre_scores_gemma":[0.9738971,0.004263766,0.008173417,0.0004293942,0.00003349255,0.0000928746,0.0009278542,0.00006359093,0.01211867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002614817,"threshold_uncertainty_score":0.008747458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07871303877346526,"score_gpt":0.4012547959021201,"score_spread":0.3225417571286548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}