{"id":"W3023355669","doi":"10.1101/2020.05.05.078642","title":"Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivo","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fondation Leducq; Deutsche Forschungsgemeinschaft; Multiple Sclerosis Society; International Progressive MS Alliance; University of Connecticut; European Committee for Treatment and Research in Multiple Sclerosis; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Institut National de la Santé et de la Recherche Médicale; National Multiple Sclerosis Society","keywords":"Remyelination; Oligodendrocyte; Multiple sclerosis; Myelin; Biology; Neuroscience; Induced pluripotent stem cell; Astrocyte; Immune system; Cell biology; Immunology; Central nervous system; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002774127,0.0001844492,0.0002278192,0.0001059298,0.0001973315,0.0002782869,0.0001414787,0.0002869298,0.004521934],"category_scores_gemma":[0.0003000829,0.0000773354,0.0001919173,0.0000665595,0.0001076496,0.0001768915,0.0001830057,0.0003914672,0.001060669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734508,"about_ca_system_score_gemma":0.0003498504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002979522,"about_ca_topic_score_gemma":0.0006491653,"domain_scores_codex":[0.9998833,0.000008807287,0.00001772112,0.00001287461,0.00006558394,0.00001168297],"domain_scores_gemma":[0.9997459,0.00005419839,0.00005467132,0.00002099365,0.00009657062,0.00002764036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001943377,0.00004171172,0.0004033409,0.0005744435,0.00001454689,0.0004600508,0.0000701777,0.0002082386,0.9566941,0.001857832,0.01650779,0.02297326],"study_design_scores_gemma":[0.00005692214,0.0005110345,0.00530579,0.00009605048,0.00006205449,0.001142726,0.0001020223,0.001340901,0.8045459,0.0007211447,0.1860881,0.00002741276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8327593,0.01148039,0.04491511,0.01124555,0.01309165,0.0005768885,0.009751882,0.002314519,0.07386469],"genre_scores_gemma":[0.8759477,0.005949454,0.01311867,0.003188022,0.001286457,0.0004622926,0.00453886,0.000509777,0.09499878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004521934,"threshold_uncertainty_score":0.01512736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05740293596780703,"score_gpt":0.203652302586103,"score_spread":0.146249366618296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}