{"id":"W3023368852","doi":"10.2147/ceor.s238725","title":"&lt;p&gt;Economic Evaluation of Single versus Combination Immuno-Oncology Therapies: Application of a Novel Modelling Approach in Metastatic Melanoma&lt;/p&gt;","year":2020,"lang":"en","type":"article","venue":"ClinicoEconomics and Outcomes Research","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Augmentium Pharma Consulting (Canada)","funders":"Bristol-Myers Squibb","keywords":"Medicine; Ipilimumab; Oncology; Progression-free survival; Regimen; Internal medicine; Clinical trial; Nivolumab; Metastatic melanoma; Cancer; Overall survival; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003178781,0.0001297445,0.0005949688,0.0003489055,0.00004964468,0.00002095048,0.000140202,0.0001028146,0.00004602185],"category_scores_gemma":[0.0001899047,0.0001287611,0.0001075693,0.0001590931,0.0001525735,0.00008061744,0.0001051177,0.0001848605,0.00001023713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221362,"about_ca_system_score_gemma":0.0002335972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006425736,"about_ca_topic_score_gemma":0.0000945479,"domain_scores_codex":[0.9980888,0.0002000987,0.0008585625,0.0003809777,0.0002586471,0.0002129453],"domain_scores_gemma":[0.9983945,0.0006932277,0.0003029311,0.0002910041,0.0002219615,0.00009630752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01225115,0.007544142,0.01741164,0.001845007,0.002520424,0.000007814337,0.01444525,0.1308415,0.0856863,0.06161408,0.0003219319,0.6655108],"study_design_scores_gemma":[0.01110011,0.001454325,0.003051872,0.00001582761,0.0001265106,0.000004707965,0.001369304,0.9786217,0.0005074002,0.0004707435,0.003155918,0.0001216382],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852804,0.0004127679,0.007037449,0.001361374,0.0001400268,0.001412618,0.00001425672,0.00001314587,0.004327984],"genre_scores_gemma":[0.9968981,0.0003896675,0.002370395,0.00008400941,0.00003460281,0.0001068617,0.00004660569,0.00002188769,0.00004785085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8477802,"threshold_uncertainty_score":0.5250723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2257659577893876,"score_gpt":0.429442170650173,"score_spread":0.2036762128607854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}