{"id":"W3023432596","doi":"10.1007/s11864-020-00746-8","title":"PI3K Inhibitors and Their Role as Novel Agents for Targeted Therapy in Lymphoma","year":2020,"lang":"en","type":"review","venue":"Current Treatment Options in Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Jewish General Hospital","funders":"","keywords":"Idelalisib; Medicine; PI3K/AKT/mTOR pathway; Adverse effect; Lymphoma; Clinical trial; Targeted therapy; Oncology; Cancer research; Pharmacology; Immunology; Internal medicine; Cancer; Signal transduction; Chronic lymphocytic leukemia; Ibrutinib; Leukemia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006314549,0.0007740636,0.001677861,0.00151067,0.0001781378,0.001108969,0.0008270378,0.0008325822,0.004965679],"category_scores_gemma":[0.0006992565,0.0002388141,0.0006203259,0.001791435,0.0003531156,0.001134096,0.0005764818,0.002139115,0.002132137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005646115,"about_ca_system_score_gemma":0.0008447567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009269548,"about_ca_topic_score_gemma":0.002236569,"domain_scores_codex":[0.9998573,0.00002620385,0.00002013771,0.00002317918,0.00005134288,0.00002181793],"domain_scores_gemma":[0.9997624,0.0001236052,0.00003896047,0.000005766675,0.00004786739,0.0000213676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002656665,0.00008697146,0.0001099016,0.01260681,0.0001388851,0.0001126184,0.00002605672,0.0004355892,0.001325912,0.002269469,0.02731068,0.9553114],"study_design_scores_gemma":[0.0002126675,0.0003318967,0.0008270814,0.003875704,0.0004619622,0.0007119542,0.00004084021,0.0002721226,0.0005268762,0.002516117,0.9901962,0.00002653658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001070993,0.9988072,0.00008339027,0.0002048561,0.0001282903,0.000004558596,0.00002503842,0.000008460816,0.0006311354],"genre_scores_gemma":[0.0007481123,0.9982111,0.0001570158,0.0002688677,0.0001388683,0.000006629728,0.00004764712,0.000001522803,0.0004202569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004965679,"threshold_uncertainty_score":0.01661187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1491848501221135,"score_gpt":0.4562154453153979,"score_spread":0.3070305951932844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}