{"id":"W3023478738","doi":"10.1101/2020.05.08.085233","title":"Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Kato Memorial Bioscience Foundation; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Akiyama Life Science Foundation; National Natural Science Foundation of China; Takeda Science Foundation; Nankai University; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; State Key Laboratory of Medicinal Chemical Biology; Canadian Light Source","keywords":"PRC2; PHD finger; Cell biology; Histone; Polycomb-group proteins; Histone H3; Gene silencing; Hox gene; Chemistry; Biology; Genetics; Gene; Zinc finger; Transcription factor; Repressor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007373134,0.0001944972,0.0001384442,0.0001585789,0.0003073654,0.0002284354,0.0003692788,0.0003280568,0.004685762],"category_scores_gemma":[0.0001679753,0.000128471,0.0002299985,0.0001110462,0.0001666771,0.000153122,0.0002346684,0.0002720814,0.0009407121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004055966,"about_ca_system_score_gemma":0.0001413469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087008,"about_ca_topic_score_gemma":0.0008704798,"domain_scores_codex":[0.9999329,0.000005204616,0.000002217624,0.00002414367,0.00001387048,0.00002164181],"domain_scores_gemma":[0.9999439,0.000009056481,0.00001386442,0.000005867899,0.00000575784,0.00002164413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004685031,0.00005594426,0.003465109,0.00008936441,0.00002219845,0.0003407542,0.00004156747,0.001086107,0.9875962,0.002558275,0.0004237624,0.003852277],"study_design_scores_gemma":[0.00007252056,0.0001631078,0.02692107,0.00001147505,0.00002155738,0.0005728378,0.00009124666,0.01409657,0.9472693,0.001654243,0.009108374,0.00001770838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873247,0.00140508,0.006038192,0.0001954431,0.00004971573,0.00001598106,0.0004018977,0.0001112728,0.004457726],"genre_scores_gemma":[0.9954994,0.0001686667,0.001434227,0.00003127788,0.000008995623,0.000006544623,0.0005921265,0.00001585515,0.002242848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004685762,"threshold_uncertainty_score":0.01567543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903781207015653,"score_gpt":0.2424746064508713,"score_spread":0.2234367943807147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}