{"id":"W3023662906","doi":"10.1126/scitranslmed.aax4517","title":"BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis","year":2020,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Prevention of Organ Failure; St. Paul's Hospital; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Danmarks Grundforskningsfond; Medical Research Council; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Research Foundation; Michael Smith Health Research BC; BC Children's Hospital; National Institutes of Health; Karen Elise Jensens Fond; Children's Hospital Foundation; Ludwig Institute for Cancer Research","keywords":"Granulopoiesis; Vaccination; Medicine; Sepsis; Neonatal sepsis; Immunology; Intensive care medicine; Virology; Biology; Haematopoiesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003759674,0.0002778598,0.0003552894,0.000195516,0.00008200264,0.0001905746,0.0001627974,0.0002867127,0.0007090471],"category_scores_gemma":[0.0003909591,0.0001061417,0.0001907155,0.00007128619,0.0002164157,0.0001641753,0.0002400713,0.0008432255,0.0002074143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001492919,"about_ca_system_score_gemma":0.0002263098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001473783,"about_ca_topic_score_gemma":0.0002232228,"domain_scores_codex":[0.9998177,0.00006422999,0.00001692626,0.00002577459,0.00002475569,0.00005060652],"domain_scores_gemma":[0.9998323,0.0000330062,0.00003828476,0.00002759368,0.00001476261,0.0000541035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002222699,0.0004818344,0.001578103,0.0001494171,0.00001842838,0.0001350986,0.00006355649,0.0001625272,0.9769641,0.000190038,0.00033537,0.01769885],"study_design_scores_gemma":[0.0004096617,0.02335754,0.05830579,0.0001122517,0.0001025347,0.001515044,0.0001076591,0.002017438,0.9059057,0.0002496669,0.007900993,0.00001578962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954248,0.002366841,0.001113811,0.0001401919,0.00007326429,0.00004440887,0.00008653052,0.00009070915,0.000659562],"genre_scores_gemma":[0.9973149,0.0008606804,0.0007876742,0.0001564233,0.00004010286,0.00004362908,0.0001894351,0.00001200689,0.0005951428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007090471,"threshold_uncertainty_score":0.002372026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04279324272135165,"score_gpt":0.2895758084937926,"score_spread":0.2467825657724409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}