{"id":"W3023670230","doi":"10.3390/biom10050706","title":"BAMBI and CHGA in Prion Diseases: Neuropathological Assessment and Potential Role as Disease Biomarkers","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"European Social Fund; European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Ministerio de Ciencia e Innovación; Gobierno de Aragón; Universidad de Zaragoza","keywords":"Scrapie; Neuropathology; Immunostaining; Western blot; Disease; Immunohistochemistry; Spongiosis; Pathology; Biology; Downregulation and upregulation; Genetically modified mouse; Medicine; Virology; Immunology; Prion protein; Transgene; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005157198,0.0001633163,0.0001245637,0.00003449334,0.00006772521,0.00006850091,0.0001054003,0.00006973197,0.00001908324],"category_scores_gemma":[0.0001002723,0.0001516793,0.00006013161,0.00008090091,0.000145421,0.000008684949,0.0002723847,0.00005596592,0.00000297789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007192921,"about_ca_system_score_gemma":0.00006663573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001229872,"about_ca_topic_score_gemma":0.000001354465,"domain_scores_codex":[0.9989007,0.0001206335,0.000154676,0.0004994024,0.0001209235,0.000203626],"domain_scores_gemma":[0.9993739,0.000006523504,0.00004528449,0.000147307,0.00001742207,0.0004095791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006992906,0.0001315794,0.05587788,0.0000756318,0.00003395139,0.0003752625,0.0000274165,0.00001233156,0.8877891,0.0003240849,0.0001457588,0.05450775],"study_design_scores_gemma":[0.002855952,0.001070982,0.9666967,0.00006391377,0.0001340704,0.00004892097,0.0003039667,0.003156785,0.01458218,0.001146174,0.009107196,0.000833132],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784245,0.01861162,0.0008095518,0.001731171,0.00003102853,0.0002601559,0.00006009245,0.00002085243,0.00005104177],"genre_scores_gemma":[0.9944702,0.003895898,0.0003507869,0.001061479,0.00008408459,0.00002556324,0.00009030216,0.00001687961,0.000004822637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9108189,"threshold_uncertainty_score":0.6185304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006562241762779818,"score_gpt":0.2551172844293816,"score_spread":0.2485550426666018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}