{"id":"W3023670230","doi":"10.3390/biom10050706","title":"BAMBI and CHGA in Prion Diseases: Neuropathological Assessment and Potential Role as Disease Biomarkers","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"European Social Fund; European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Ministerio de Ciencia e Innovación; Gobierno de Aragón; Universidad de Zaragoza","keywords":"Scrapie; Neuropathology; Immunostaining; Western blot; Disease; Immunohistochemistry; Spongiosis; Pathology; Biology; Downregulation and upregulation; Genetically modified mouse; Medicine; Virology; Immunology; Prion protein; Transgene; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003646897,0.0005423214,0.0002064837,0.001204913,0.0001231122,0.0004442287,0.0001431217,0.0004554665,0.000377259],"category_scores_gemma":[0.0002821269,0.0001500101,0.00007790245,0.0004077912,0.0004182778,0.0003991726,0.000167732,0.0003300482,0.000127877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491903,"about_ca_system_score_gemma":0.0001208173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000288738,"about_ca_topic_score_gemma":0.0003833396,"domain_scores_codex":[0.9998912,0.00004381418,0.000008757404,0.00001961566,0.00002356305,0.00001314062],"domain_scores_gemma":[0.9997919,0.00004937834,0.00007574316,0.00001316326,0.00002813015,0.00004161326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003373009,0.00005265842,0.01051821,0.0002221138,0.00002339231,0.0003703842,0.00006742505,0.00005706197,0.9816017,0.0001500834,0.00003164567,0.006567953],"study_design_scores_gemma":[0.00004897856,0.002028849,0.383625,0.0001473811,0.0001810296,0.007591609,0.000516529,0.001666692,0.5965819,0.001436704,0.006135745,0.00003961831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697679,0.02609144,0.002661862,0.0001247715,0.00002087679,0.0000317337,0.0001561307,0.00003815104,0.001107094],"genre_scores_gemma":[0.9892324,0.005521611,0.004309935,0.00003905714,0.00002888785,0.00002483018,0.0001645288,0.000004667909,0.0006740611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204913,"threshold_uncertainty_score":0.001928687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006562241762779818,"score_gpt":0.2551172844293816,"score_spread":0.2485550426666018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}