{"id":"W3023706702","doi":"10.1210/jendso/bvaa046.1590","title":"SAT-158 New Data on High Prevalence and Time of Occurrence of New Onset Hypothyroidism Associated with Mitotane Therapy in a Cohort of Adrenocortical Cancer","year":2020,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Mitotane; Medicine; Levothyroxine; Internal medicine; Thyroid; Adrenocortical carcinoma; Thyroid function tests; Thyroid function; Cohort; Endocrinology; Context (archaeology); Retrospective cohort study; Hormone; Propylthiouracil; Thyroid cancer; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004970144,0.000141439,0.0003571676,0.001792419,0.0003306413,0.0006371344,0.0002827133,0.000257746,0.00209575],"category_scores_gemma":[0.002530286,0.0001770575,0.0003252172,0.001606919,0.0001770661,0.0003663792,0.0003570489,0.0002417833,0.0003190244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003214703,"about_ca_system_score_gemma":0.0003019233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002886466,"about_ca_topic_score_gemma":0.002664811,"domain_scores_codex":[0.9994903,0.00008108062,0.00009663308,0.0001342705,0.0001219094,0.00007589215],"domain_scores_gemma":[0.9966835,0.0007800934,0.001603029,0.0002642904,0.0003476913,0.000321438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000478354,0.00000646497,0.9987457,0.000007695397,0.00001198373,0.0001461237,0.00002313081,0.00001151572,0.0002165579,0.000004310626,0.00003926197,0.0007394281],"study_design_scores_gemma":[0.000002770991,0.00004058128,0.9984458,0.000003498433,0.00001172656,0.001111048,0.00006127795,0.00005320657,0.00007876661,0.000004002861,0.0001856994,0.000001540214],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981446,0.0005474256,0.00006916319,0.00001762522,0.000005307117,0.000005637475,0.0007922678,0.000005614908,0.0004123046],"genre_scores_gemma":[0.9984999,0.0001789009,0.00004707667,0.00001263266,0.00001293919,0.000006529559,0.001169449,0.00000197752,0.00007056236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002886466,"threshold_uncertainty_score":0.007010996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206716554237166,"score_gpt":0.2725462911509173,"score_spread":0.2504791256085456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}