{"id":"W3023733452","doi":"10.1101/2020.05.04.077727","title":"Cholesterol Sequestration by Xenon Leads to Lipid Raft Destabilization","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Australian Dental Research Foundation; Canada Research Chairs; Compute Canada","keywords":"Raft; Lipid raft; Nucleation; Chemistry; Xenon; Biophysics; Membrane; Lipid bilayer; Molecular dynamics; Chemical physics; Nanoclusters; Biological membrane; Tetramethylammonium; Computational chemistry; Biochemistry; Ion; Biology; Organic chemistry; Polymerization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008729323,0.0001997143,0.0002987692,0.0001273197,0.0002804066,0.0003522744,0.0003093843,0.0002855936,0.00116692],"category_scores_gemma":[0.0002764796,0.0001616298,0.0002224469,0.0001179616,0.0004394698,0.0003004605,0.000384584,0.0003422775,0.0001053946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005074288,"about_ca_system_score_gemma":0.0005425417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00614822,"about_ca_topic_score_gemma":0.003799197,"domain_scores_codex":[0.9999281,0.000008855605,0.00000241814,0.00001040117,0.00001736511,0.00003277942],"domain_scores_gemma":[0.9999208,0.00002809817,0.00001608337,0.000006093944,0.000008781382,0.0000199877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001089312,0.000152295,0.008576078,0.0001838997,0.0001102638,0.001138531,0.0002857526,0.2470844,0.7318076,0.005690115,0.0005041518,0.003377507],"study_design_scores_gemma":[0.0001491254,0.0003170828,0.005869825,0.00001293953,0.00004399567,0.0001300594,0.000170195,0.5874597,0.4038886,0.0009556025,0.0009671223,0.00003584495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986991,0.00005011129,0.0006429194,0.00004217721,0.000004541761,0.00000359962,0.0000250656,0.00002664354,0.0005059052],"genre_scores_gemma":[0.9993582,0.0000554712,0.0003175669,0.00001120615,8.395942e-7,0.000004954355,0.00002409919,0.00001070462,0.0002169889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00614822,"threshold_uncertainty_score":0.01222485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218975049309805,"score_gpt":0.2340715281489275,"score_spread":0.2218817776558294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}