{"id":"W3023749697","doi":"","title":"Germline CRISPR/Cas9-mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia","year":2019,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"CRISPR; Aniridia; Genome editing; PAX6; Germline; Cas9; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004570401,0.001040115,0.0005224026,0.0016129,0.0006056037,0.000855473,0.0009164988,0.001363434,0.003277662],"category_scores_gemma":[0.0003420167,0.0004914466,0.0005948087,0.0003690932,0.001053907,0.0005551901,0.000505941,0.001931435,0.0006350112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005996507,"about_ca_system_score_gemma":0.0005123829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121097,"about_ca_topic_score_gemma":0.002229871,"domain_scores_codex":[0.9994348,0.00006485583,0.00007538001,0.0001736816,0.0001748436,0.00007629664],"domain_scores_gemma":[0.9993812,0.00008953457,0.0002403065,0.00006549677,0.00004020542,0.0001832951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002820108,0.0001922111,0.00016583,0.00004509437,0.00002275025,0.000721532,0.00004572437,0.0002019181,0.9954755,0.001161462,0.0002197897,0.001466156],"study_design_scores_gemma":[0.0002660696,0.000818379,0.006711824,0.00006371959,0.0001616069,0.004682187,0.0001310852,0.006026697,0.9735427,0.0008934653,0.006652341,0.00004986149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97396,0.0009417404,0.01765978,0.0005398088,0.0002747469,0.0001529021,0.001533821,0.0009785866,0.003958768],"genre_scores_gemma":[0.9724419,0.001008888,0.01126445,0.0001808948,0.00004493564,0.0001335646,0.0006607746,0.0002396957,0.01402499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003277662,"threshold_uncertainty_score":0.01096487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02799974185988836,"score_gpt":0.329122420471554,"score_spread":0.3011226786116657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}