{"id":"W3023763939","doi":"10.1186/s13287-020-01679-7","title":"MiR-153 reduces stem cell-like phenotype and tumor growth of lung adenocarcinoma by targeting Jagged1","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Natural Science Foundation of Shandong Province; McMaster University","keywords":"Stem cell; Phenotype; Biology; Cancer stem cell; Cancer research; Adenocarcinoma; Lung; Cell biology; Medicine; Internal medicine; Gene; Genetics; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042248,0.0003260933,0.0005320976,0.0003352824,0.0001518251,0.0002719049,0.0002821925,0.0003765731,0.001141391],"category_scores_gemma":[0.0001822194,0.0001618749,0.0003844322,0.0001730052,0.0003761958,0.0001713579,0.0001495271,0.0006422296,0.0003406612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004515277,"about_ca_system_score_gemma":0.000327842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000477086,"about_ca_topic_score_gemma":0.0007062885,"domain_scores_codex":[0.999816,0.0000307651,0.00003225923,0.00002888661,0.00005645361,0.00003556925],"domain_scores_gemma":[0.9998775,0.00002158768,0.0000372232,0.00001457095,0.00001555536,0.00003359374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000394437,0.00009444328,0.0003659016,0.00009467467,0.00001364811,0.00004988329,0.00001675307,0.00005333913,0.997248,0.00006656058,0.0001083572,0.001493995],"study_design_scores_gemma":[0.00008017841,0.001179558,0.005277783,0.000009235536,0.00005963578,0.0003731619,0.00003721956,0.000825373,0.9894297,0.00004818903,0.002673487,0.00000649793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914883,0.003805202,0.002237344,0.0001840144,0.0000736581,0.00005774657,0.0003289869,0.0002917455,0.001533024],"genre_scores_gemma":[0.995413,0.0008715199,0.001922688,0.0001277435,0.00001251416,0.00006705715,0.0004204375,0.00003480001,0.001130422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141391,"threshold_uncertainty_score":0.003818333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564924377786041,"score_gpt":0.279899271878683,"score_spread":0.2542500281008226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}