{"id":"W3023775962","doi":"10.1016/j.immuni.2020.04.001","title":"Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":428,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of California, San Diego; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Manpei Suzuki Diabetes Foundation; National Institute of General Medical Sciences; American Heart Association; Israel National Road Safety Authority; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fondation Leducq","keywords":"Biology; Kupffer cell; Steatohepatitis; Epigenetics; Reprogramming; TREM2; Phenotype; Macrophage; Cell biology; Transcriptome; Cell; Immunology; Gene expression; Cancer research; Fatty liver; Gene; Genetics; Pathology; Inflammation; Microglia; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008232626,0.000122095,0.0003013305,0.00005897134,0.00008740955,0.000008649128,0.0001238927,0.00004823174,0.0001486922],"category_scores_gemma":[0.00002993973,0.000112346,0.0001264216,0.0002235609,0.00005023253,0.00006097902,0.0002448784,0.0001469225,0.00004233467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004686139,"about_ca_system_score_gemma":0.00004094297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009926967,"about_ca_topic_score_gemma":0.00007018744,"domain_scores_codex":[0.9991323,0.00008415971,0.0002138513,0.000207729,0.0001913884,0.0001705887],"domain_scores_gemma":[0.999338,0.00008419265,0.00007719357,0.0002938379,0.00005712776,0.0001496809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001149855,0.0008458964,0.9889094,0.0001216182,0.00006660387,0.00008437299,0.003030531,0.000008909761,0.001656259,0.00001790748,0.00008147124,0.005062011],"study_design_scores_gemma":[0.001919469,0.0003264971,0.9801602,0.00007557306,0.0001045328,0.000001563977,0.0006045664,0.00003619136,0.01580262,0.00002220591,0.0008494896,0.00009707896],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949739,0.003235699,0.00001028411,0.0004098037,0.00003016695,0.0003116717,0.00002870094,0.00002980772,0.0009699582],"genre_scores_gemma":[0.9979962,0.001439322,0.0002670815,0.0001569671,0.00003051286,0.00001460937,0.00006672146,0.00001031694,0.00001830182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01414636,"threshold_uncertainty_score":0.4581338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04008052906959009,"score_gpt":0.2547919469848446,"score_spread":0.2147114179152546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}