{"id":"W3023788516","doi":"10.1126/science.aax4040","title":"PIRs mediate innate myeloid cell memory to nonself MHC molecules","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto; Hospital for Sick Children","funders":"NIH Office of the Director; National Heart, Lung, and Blood Institute; Breakthrough T1D Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Innate immune system; Immunology; Immune system; Major histocompatibility complex; Biology; Antigen; Myeloid; Innate lymphoid cell; Acquired immune system; Transplantation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003801351,0.0005424315,0.0002810597,0.0002196954,0.0002664012,0.0007226122,0.0003616735,0.0003998583,0.006946466],"category_scores_gemma":[0.0002331901,0.0001883629,0.0003134658,0.00008134779,0.00046269,0.0007747942,0.001104904,0.001233189,0.002643699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517692,"about_ca_system_score_gemma":0.0002112465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004961668,"about_ca_topic_score_gemma":0.00008036241,"domain_scores_codex":[0.9997799,0.00004188708,0.00001170673,0.00004535427,0.00005153182,0.0000697294],"domain_scores_gemma":[0.999836,0.00002185733,0.00003019875,0.00001690088,0.00001595643,0.00007910596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008925377,0.0001575012,0.0005043143,0.0002913988,0.00002277823,0.000336128,0.0000848242,0.0001655995,0.9711168,0.005702542,0.002020841,0.01870476],"study_design_scores_gemma":[0.0002415529,0.001923399,0.01073638,0.00007450127,0.00004618804,0.0009402963,0.0001941458,0.002042081,0.9345703,0.004576825,0.04463157,0.00002261362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8791721,0.03659927,0.02202356,0.002281019,0.001562855,0.0002727952,0.0007487061,0.0009988537,0.05634081],"genre_scores_gemma":[0.9746351,0.004015231,0.004141507,0.0005174433,0.0002971438,0.00008297327,0.0005299703,0.00006843027,0.01571231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006946466,"threshold_uncertainty_score":0.0232383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246255098995274,"score_gpt":0.2450869089112663,"score_spread":0.2326243579213136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}