{"id":"W3023793899","doi":"10.1038/s41388-020-1315-3","title":"Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers","year":2020,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Biology; Cancer research; Ectopic expression; Carcinogenesis; Protein kinase B; Breast cancer; Conditional gene knockout; Stem cell; Signal transduction; Cancer; Phenotype; Cell biology; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262665,0.0001669513,0.0003948497,0.00004549874,0.00003582356,0.000008257219,0.0001557705,0.00007257039,0.0001884204],"category_scores_gemma":[0.00001177239,0.000120754,0.0001378249,0.0005554159,0.0001132981,0.00004452253,0.00008997595,0.000203084,0.00001749793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002431622,"about_ca_system_score_gemma":0.0005621701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002650309,"about_ca_topic_score_gemma":0.0009452733,"domain_scores_codex":[0.9987864,0.00007421759,0.0002832466,0.0002976609,0.0003157197,0.0002427823],"domain_scores_gemma":[0.9992833,0.0000289279,0.0001318265,0.0002815072,0.00009621571,0.0001782649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003890978,0.0009388018,0.07071488,0.00141603,0.0008377598,0.0006473003,0.0126821,0.0004840033,0.6689017,0.000161691,0.01130192,0.2280228],"study_design_scores_gemma":[0.01510405,0.001842144,0.09904772,0.002334626,0.001313443,0.0001973242,0.006299022,0.000283432,0.7608301,0.00006735568,0.1115262,0.001154589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902688,0.001884411,0.00001661605,0.003741288,0.0003860528,0.0004298889,0.0002120459,0.00001754313,0.003043401],"genre_scores_gemma":[0.9952571,0.0002307944,0.0001347799,0.003648366,0.0002279868,0.000019894,0.00001371407,0.00003016129,0.0004371739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2268682,"threshold_uncertainty_score":0.4924206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02241407966003942,"score_gpt":0.2611012577176264,"score_spread":0.238687178057587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}