{"id":"W3023794924","doi":"10.1074/jbc.ra119.012348","title":"Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Innovates; Alberta Innovates - Health Solutions; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Campus Alberta Neuroscience","keywords":"Chemistry; Scrapie; Biochemistry; Biophysics; Amphiphile; Lipid bilayer; Membrane; Biology; Polymer; Copolymer; Prion protein; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006433384,0.0002128252,0.0001497016,0.0001121348,0.00008061971,0.0001908501,0.0001263001,0.0001916982,0.0003987918],"category_scores_gemma":[0.00007271268,0.0000927823,0.0001554471,0.0000597488,0.00009575536,0.0001896472,0.000108395,0.0002240598,0.0001831712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602149,"about_ca_system_score_gemma":0.00007002224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001709794,"about_ca_topic_score_gemma":0.0003730759,"domain_scores_codex":[0.9999447,0.000005212258,0.000007315453,0.00001045342,0.00002036659,0.00001194623],"domain_scores_gemma":[0.9999436,0.00000987387,0.00002136934,0.000005650076,0.000006800483,0.00001272379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001297125,0.000006990334,0.00003844413,0.00001144838,0.000001916186,0.00001722784,0.000004375536,0.00002176722,0.9995404,0.00002147521,0.000007328692,0.0003155641],"study_design_scores_gemma":[0.000001962524,0.00005704847,0.0007493543,0.000001821226,0.000004416264,0.00005817819,0.00000499248,0.0003221971,0.9983163,0.000006906114,0.0004755604,0.000001267661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995095,0.0007018748,0.003275326,0.00003503554,0.00001650045,0.00001595683,0.0000925687,0.00006236273,0.0007054274],"genre_scores_gemma":[0.995003,0.0005162172,0.002982515,0.00004109957,0.000005511036,0.00001184275,0.0001681432,0.00001989599,0.0012518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003987918,"threshold_uncertainty_score":0.001334071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604251851786648,"score_gpt":0.2614661277078728,"score_spread":0.2454236091900063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}