{"id":"W3023810398","doi":"10.1158/1078-0432.ccr-19-3402","title":"Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase Ib Study","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec; BC Cancer Agency","funders":"Janssen Research and Development; Cancer Research UK","keywords":"Abiraterone acetate; Prednisone; Prostate cancer; Medicine; Pharmacokinetics; Pharmacology; Adverse effect; Enzalutamide; Internal medicine; Antiandrogen; Cancer; Urology; Oncology; Androgen receptor; Androgen deprivation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009121365,0.0007639876,0.001728101,0.000370777,0.0003630541,0.0008198059,0.0005853419,0.0004898662,0.001451466],"category_scores_gemma":[0.001079082,0.0005019894,0.0009901362,0.0004992028,0.0006180327,0.0005525168,0.0002567226,0.001651546,0.0004126612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00107961,"about_ca_system_score_gemma":0.001605124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001775654,"about_ca_topic_score_gemma":0.00308167,"domain_scores_codex":[0.9992106,0.0003363862,0.00004346003,0.0001424304,0.0001666657,0.0001004515],"domain_scores_gemma":[0.9990625,0.0001277987,0.0002640088,0.00007586416,0.00005943401,0.0004104101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4519167,0.06500266,0.04290291,0.0006276311,0.003043928,0.0006573708,0.0005585241,0.005237408,0.2835657,0.0001288217,0.001544053,0.1448143],"study_design_scores_gemma":[0.1282605,0.7196939,0.1056874,0.0000429403,0.001716075,0.002145874,0.000156192,0.005374771,0.0335495,0.0001295199,0.003163418,0.00007978844],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998638,0.0006343958,0.000194159,0.00003678986,0.000009639339,0.0001344814,0.00009998462,0.00002271799,0.000229932],"genre_scores_gemma":[0.9982838,0.0003910759,0.0004905961,0.0000683775,0.00004153951,0.0001016213,0.0003471218,0.00001195913,0.0002639238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775654,"threshold_uncertainty_score":0.007833123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.179114971217851,"score_gpt":0.5338944760008876,"score_spread":0.3547795047830366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}