{"id":"W3023832122","doi":"10.1186/s13195-020-00620-7","title":"The cholinergic system in subtypes of Alzheimer’s disease: an in vivo longitudinal MRI study","year":2020,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; IXICO; Servier; Karolinska Institutet; Vetenskapsrådet; Eisai; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Stockholms Läns Landsting; Pfizer; Biogen; BioClinica; Alzheimer's Association; Åke Wiberg Stiftelse; F. Hoffmann-La Roche; Medpace; Demensförbundet; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Synarc; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Geriatric psychiatry; Neurology; Disease; Cholinergic; Medicine; Neuroscience; In vivo; Cholinergic system; Psychopharmacology; Alzheimer's disease; Pathology; Internal medicine; Psychology; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001781191,0.0004610863,0.0004687409,0.0005667398,0.0006372319,0.0005137767,0.0004689694,0.0006857697,0.0009094476],"category_scores_gemma":[0.001696432,0.0003811653,0.0004044404,0.0003352248,0.0004565058,0.0005699951,0.0003770341,0.0007210094,0.0005337537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003782679,"about_ca_system_score_gemma":0.0003247893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003510107,"about_ca_topic_score_gemma":0.003573503,"domain_scores_codex":[0.9997268,0.00008063193,0.00002317677,0.00007758735,0.00003662525,0.00005526688],"domain_scores_gemma":[0.999029,0.0001177436,0.0002911142,0.0001870603,0.0001906564,0.000184436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01530764,0.00403171,0.92251,0.00008345921,0.0005462071,0.001401686,0.001293629,0.0002460692,0.03463331,0.00005805216,0.0003105457,0.01957764],"study_design_scores_gemma":[0.0002494714,0.004338811,0.9905967,0.00001395992,0.000160177,0.002045324,0.0001725551,0.0002477695,0.001407007,0.0000723397,0.0006803399,0.00001566368],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991437,0.0003220437,0.0001187666,0.0000205796,0.000003095171,0.00003325094,0.00009000138,0.000003421862,0.0002650924],"genre_scores_gemma":[0.9984254,0.0002140346,0.0003594188,0.00003762934,0.00001453612,0.0000480687,0.0005181933,0.000004727148,0.0003779804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003510107,"threshold_uncertainty_score":0.009419978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2305284364940795,"score_gpt":0.4120035408333846,"score_spread":0.1814751043393051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}