{"id":"W3023832122","doi":"10.1186/s13195-020-00620-7","title":"The cholinergic system in subtypes of Alzheimer’s disease: an in vivo longitudinal MRI study","year":2020,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; IXICO; Servier; Karolinska Institutet; Vetenskapsrådet; Eisai; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Stockholms Läns Landsting; Pfizer; Biogen; BioClinica; Alzheimer's Association; Åke Wiberg Stiftelse; F. Hoffmann-La Roche; Medpace; Demensförbundet; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Synarc; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Geriatric psychiatry; Neurology; Disease; Cholinergic; Medicine; Neuroscience; In vivo; Cholinergic system; Psychopharmacology; Alzheimer's disease; Pathology; Internal medicine; Psychology; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001863404,0.0001829367,0.0002625205,0.0002104086,0.0003152553,0.0001216794,0.0007924158,0.00005688781,0.00003705926],"category_scores_gemma":[0.0001362158,0.0001212235,0.00006833709,0.00136752,0.0003120677,0.000331964,0.0001167927,0.0004876513,0.00002505071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002620986,"about_ca_system_score_gemma":0.0001710027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003406384,"about_ca_topic_score_gemma":0.0003408059,"domain_scores_codex":[0.9950755,0.002235253,0.000491433,0.000645999,0.001016388,0.0005354343],"domain_scores_gemma":[0.9985799,0.0003976168,0.00008891944,0.0005725765,0.0001235191,0.0002374482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009172734,0.004638109,0.1289205,0.00005622076,0.0004141899,0.0009634974,0.01085119,0.006028531,0.8019493,0.01317943,0.003093066,0.02073319],"study_design_scores_gemma":[0.003841362,0.003143745,0.08097515,0.00007770454,0.00006341119,0.000006950076,0.002967701,0.02118005,0.8829165,0.0002765571,0.004018739,0.0005321805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851769,0.01069855,0.000005393677,0.00209995,0.0001402478,0.001551493,0.00001509143,0.00004174384,0.000270649],"genre_scores_gemma":[0.9985614,0.0008844764,0.000009070228,0.0001053556,0.0001969247,0.0001874061,0.000002071963,0.00002817806,0.00002506974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08096712,"threshold_uncertainty_score":0.4943352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2305284364940795,"score_gpt":0.4120035408333846,"score_spread":0.1814751043393051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}