{"id":"W3023842701","doi":"","title":"Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma","year":2018,"lang":"en","type":"article","venue":"","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"PI3K/AKT/mTOR pathway; TFE3; Cancer research; Protein kinase B; Biology; TFEB; Clear cell renal cell carcinoma; Renal cell carcinoma; Cell biology; Signal transduction; Medicine; Pathology; Transcription factor; Gene; Genetics; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088377,0.0003280544,0.0003259892,0.0002359139,0.0002069066,0.0002818042,0.0001959243,0.000333742,0.001730585],"category_scores_gemma":[0.0001488954,0.00007934229,0.0003747126,0.0002125193,0.0002528167,0.0001717509,0.0001888922,0.0006198239,0.0003765022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356314,"about_ca_system_score_gemma":0.0003408263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004931197,"about_ca_topic_score_gemma":0.0009775409,"domain_scores_codex":[0.9998817,0.00001241664,0.000008521206,0.00002838758,0.00004083946,0.00002805704],"domain_scores_gemma":[0.9999423,0.000008991912,0.00002041235,0.000006874831,0.000007539868,0.00001389503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000476005,0.0001360973,0.001668233,0.0001674635,0.00003327239,0.0002216232,0.00002430141,0.000715535,0.9842307,0.0002512185,0.0004784574,0.01159711],"study_design_scores_gemma":[0.0002091928,0.001798132,0.01333223,0.00002532898,0.0001120143,0.002600668,0.00007491793,0.004310818,0.9641514,0.0002807356,0.01308531,0.00001914391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827168,0.005503356,0.007497245,0.0004382602,0.00007515423,0.0001112035,0.001009284,0.000442126,0.002206522],"genre_scores_gemma":[0.9942005,0.0009936064,0.003245466,0.00009278957,0.00001016729,0.0000494897,0.0005825218,0.00002652398,0.0007989473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001730585,"threshold_uncertainty_score":0.005789399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438403106138557,"score_gpt":0.2600881287832605,"score_spread":0.2357040977218749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}