{"id":"W3023957398","doi":"10.1016/j.clml.2020.04.014","title":"Drug-induced Thrombotic Microangiopathy with Concurrent Proteasome Inhibitor Use in the Treatment of Multiple Myeloma: A Case Series and Review of the Literature","year":2020,"lang":"en","type":"review","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre; Hôtel-Dieu de Québec; University of Ottawa; Ottawa Hospital; Princess Margaret Cancer Centre; University of Toronto; Université Laval; University of Alberta; Queen's University","funders":"Johnson and Johnson; Alexion Pharmaceuticals; Bristol-Myers Squibb Canada; Gilead Sciences; Sanofi; Amgen Canada; Queen's University; Amgen","keywords":"Medicine; Thrombotic microangiopathy; Carfilzomib; Bortezomib; Multiple myeloma; Proteasome inhibitor; Internal medicine; Dexamethasone; Cyclophosphamide; Melphalan; Oncology; Gastroenterology; Pharmacology; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006300558,0.0008498526,0.003958185,0.0001027408,0.000152344,0.00004506224,0.0007005802,0.0004845879,0.00002523147],"category_scores_gemma":[0.000821553,0.0004091485,0.001208204,0.0007168261,0.0008297815,0.0001260427,0.000277673,0.0004287287,0.00002075303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754751,"about_ca_system_score_gemma":0.001498442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000109397,"about_ca_topic_score_gemma":0.0001912498,"domain_scores_codex":[0.9923595,0.003537606,0.002614772,0.000898551,0.0001534468,0.000436176],"domain_scores_gemma":[0.9939762,0.002653298,0.001781782,0.001329978,0.000180941,0.00007775637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002405215,0.0009355256,0.001757968,0.06815258,0.001075927,0.001205987,0.001052364,4.081125e-8,0.00004203516,0.00008848296,0.00128665,0.9241619],"study_design_scores_gemma":[0.004038796,0.001844721,0.009243663,0.2113498,0.003168141,0.009408748,0.0002684078,4.85987e-7,0.0001233352,0.0000069166,0.7599085,0.0006384895],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1035584,0.8889107,2.379173e-7,0.0001298957,0.0005452114,0.005927828,0.0008918566,0.00002756867,0.00000828141],"genre_scores_gemma":[0.05651377,0.9419395,0.00002536828,0.0001255391,0.0001330389,0.0008228427,0.0003040571,0.00006058355,0.00007532263],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9235234,"threshold_uncertainty_score":0.999836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05581774254767308,"score_gpt":0.3291006389050129,"score_spread":0.2732828963573398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}