{"id":"W3024052851","doi":"10.1016/j.tim.2020.03.007","title":"The Conformational States of the HIV-1 Envelope Glycoproteins","year":2020,"lang":"en","type":"review","venue":"Trends in Microbiology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Gilead Sciences","keywords":"Biology; Glycoprotein; Envelope (radar); Human immunodeficiency virus (HIV); Virology; Cell biology; Computational biology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002924182,0.0003564448,0.001115962,0.0001802413,0.0002213589,0.00001197067,0.0009823068,0.0004651537,0.0009504606],"category_scores_gemma":[0.00007845523,0.0001649635,0.0004238063,0.000461826,0.0009375248,0.0000240218,0.0003909224,0.0008477995,0.002709393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130749,"about_ca_system_score_gemma":0.000396193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004566757,"about_ca_topic_score_gemma":0.000149374,"domain_scores_codex":[0.9974242,0.0008944591,0.0008059638,0.0003147974,0.00002741358,0.0005330981],"domain_scores_gemma":[0.9984586,0.0005879014,0.0004087352,0.0004779405,0.00004506802,0.00002173074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004822759,0.00006764815,0.00003295178,0.0004016881,0.0006162697,0.000007173849,0.0001878478,4.74344e-7,0.0001880109,0.0005212349,0.02463014,0.9732983],"study_design_scores_gemma":[0.000588354,0.0001007519,0.0000469266,0.0004752872,0.00009385208,0.000184598,0.00003221435,8.918566e-8,0.0001443809,0.00002252792,0.9981657,0.0001453681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003279441,0.9936374,0.000002423857,0.000641018,0.0003865389,0.000492873,0.003497918,0.00001679966,0.001292207],"genre_scores_gemma":[0.0002247584,0.9875692,0.00002059225,0.00004199989,0.00002277453,0.0001700958,0.006308628,0.00002094354,0.005621005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9735355,"threshold_uncertainty_score":0.9999628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03097264236240625,"score_gpt":0.3140873545688698,"score_spread":0.2831147122064635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}