{"id":"W3024140734","doi":"10.1002/9781119187547.ch17","title":"Clinical Validation and Biomarker Translation","year":2020,"lang":"en","type":"other","venue":"","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure","funders":"","keywords":"Biomarker; Biomarker discovery; Food and drug administration; Computer science; Translational research; Bench to bedside; Data science; Risk analysis (engineering); Medicine; Proteomics; Computational biology; Medical physics; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002049729,0.0001258064,0.0002723746,0.00005097759,0.00001788298,0.00001049914,0.00005606536,0.0008046615,0.01635158],"category_scores_gemma":[0.0000386179,0.00009020888,0.00007864084,0.00005534298,0.0001622272,0.00001288242,0.00002138175,0.0001908223,0.0002514525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001934561,"about_ca_system_score_gemma":0.00001074125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001947912,"about_ca_topic_score_gemma":0.00001023141,"domain_scores_codex":[0.9991702,0.0002339351,0.0002125414,0.0002704055,0.00001418184,0.00009866345],"domain_scores_gemma":[0.9996878,0.0001104916,0.00007172365,0.0001023629,0.000005667294,0.00002193732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002487549,0.00002343282,0.0002956543,0.0000229548,0.000204878,6.418599e-7,0.000004255741,6.22948e-10,0.002076921,0.0003681472,0.7378621,0.2591161],"study_design_scores_gemma":[0.0004054194,0.00005522279,0.0005233602,0.00002197346,0.0001099108,0.000003411467,0.000005498733,0.000005259241,0.0008108946,0.00008271275,0.9978503,0.000126041],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00001054914,0.005903443,0.006285025,0.002360331,0.0007720898,0.0002266258,0.00004310239,0.0001853854,0.9842135],"genre_scores_gemma":[0.00104261,0.00168773,0.0165351,0.001352259,0.0001596885,0.000004273699,0.0001973183,0.000149563,0.9788715],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2599882,"threshold_uncertainty_score":0.9845476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1014800801377704,"score_gpt":0.3788395730987731,"score_spread":0.2773594929610027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}