{"id":"W3024140734","doi":"10.1002/9781119187547.ch17","title":"Clinical Validation and Biomarker Translation","year":2020,"lang":"en","type":"other","venue":"","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure","funders":"","keywords":"Biomarker; Biomarker discovery; Food and drug administration; Computer science; Translational research; Bench to bedside; Data science; Risk analysis (engineering); Medicine; Proteomics; Computational biology; Medical physics; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09104395,0.001781824,0.002403905,0.005460701,0.001551593,0.01209554,0.002811891,0.004643966,0.02152103],"category_scores_gemma":[0.1478329,0.0009324672,0.001699833,0.002853657,0.008342375,0.006372754,0.008759131,0.007542538,0.01913398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004779557,"about_ca_system_score_gemma":0.01497015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003246648,"about_ca_topic_score_gemma":0.001727574,"domain_scores_codex":[0.9412637,0.0278846,0.006073331,0.005206166,0.01823206,0.001340206],"domain_scores_gemma":[0.8893483,0.04924694,0.007046798,0.01525329,0.03647334,0.00263129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002983444,0.0002009714,0.005608734,0.00258536,0.0001614639,0.0006023552,0.0007646108,0.001062654,0.002836236,0.12457,0.09537718,0.7659323],"study_design_scores_gemma":[0.0001040756,0.0004381127,0.003795542,0.006324827,0.0001456268,0.0022709,0.0005713449,0.00146275,0.005596393,0.07611965,0.9030749,0.00009581512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.007787447,0.1667577,0.3009552,0.1523341,0.02278587,0.00315348,0.0037299,0.003067175,0.339429],"genre_scores_gemma":[0.2054895,0.2205269,0.3264445,0.1227377,0.02522883,0.004923733,0.007868662,0.00351119,0.08326912],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.09104395,"threshold_uncertainty_score":0.4814922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1014800801377704,"score_gpt":0.3788395730987731,"score_spread":0.2773594929610027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}