{"id":"W3024257894","doi":"10.1111/imm.13207","title":"Circles of Life: linking metabolic and epigenetic cycles to immunity","year":2020,"lang":"en","type":"review","venue":"Immunology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Cancer Institute; Case Comprehensive Cancer Center, Case Western Reserve University; Cancer Research Institute","keywords":"Epigenetics; Epigenome; Biology; Metabolome; DNA methylation; Epigenomics; Histone; Function (biology); Epigenetic regulation of neurogenesis; Cell biology; Genetics; Metabolomics; DNA; Gene; Histone methyltransferase; Bioinformatics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002045212,0.0003186864,0.001203196,0.0001443179,0.00006651387,0.0000170691,0.0003676709,0.0005315232,0.000009337987],"category_scores_gemma":[0.0003050998,0.0003096623,0.0002334961,0.0001639617,0.0001382767,0.000001605745,0.0004930038,0.0002409478,0.00001748959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008110853,"about_ca_system_score_gemma":0.0002303292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003750877,"about_ca_topic_score_gemma":0.00001144904,"domain_scores_codex":[0.9982689,0.0003435374,0.0006063844,0.0004480674,0.00008263183,0.0002504526],"domain_scores_gemma":[0.9988927,0.0000642239,0.0003261247,0.0005346863,0.00007713741,0.0001051616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001359705,0.0000232293,0.00004572078,0.0009640595,0.0003934401,0.00000126019,0.00004895653,0.000002385804,0.02209329,0.0001065998,0.000007521977,0.9762999],"study_design_scores_gemma":[0.0001515085,0.0002571267,0.0005755345,0.0004526123,0.0002730867,0.000006387501,0.00001376077,7.761801e-7,0.007116281,0.0001355507,0.9907228,0.0002945646],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009535667,0.9890826,0.00056443,0.00003750717,0.0002149662,0.0003848709,0.00004752082,0.00001071798,0.0001217173],"genre_scores_gemma":[0.006993782,0.9916407,0.0007875056,0.00004172718,0.0002037315,0.00004495547,0.0002058447,0.00005559286,0.00002611716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907153,"threshold_uncertainty_score":0.9999356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02954830110085185,"score_gpt":0.312405647996345,"score_spread":0.2828573468954931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}