{"id":"W3024275141","doi":"10.3389/fnmol.2020.00067","title":"D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis","year":2020,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, State of Israel; Azrieli Foundation; Israel Science Foundation; International Development Research Centre; Canadian Institutes of Health Research; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Dopamine; Dopamine receptor D1; Dopamine receptor; Dopamine receptor D3; Biology; Neuroscience; Dephosphorylation; Dopamine receptor D2; Cell biology; Translation (biology); Dopaminergic; Phosphorylation; Messenger RNA; Phosphatase; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026405,0.0002238364,0.000195071,0.00008052676,0.00009910241,0.00007414813,0.0004968418,0.0001278478,0.00002511609],"category_scores_gemma":[0.0005205041,0.0002288142,0.00006936561,0.0003218858,0.00009797053,0.00002076084,0.0001682813,0.0002071769,0.000004979112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000226615,"about_ca_system_score_gemma":0.0001223375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008224519,"about_ca_topic_score_gemma":5.282068e-7,"domain_scores_codex":[0.9980082,0.0001683833,0.000267888,0.0007883226,0.0004018984,0.0003652983],"domain_scores_gemma":[0.9994063,0.000006472118,0.0001212889,0.0002608412,0.00003789169,0.0001672216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000628266,0.00004426372,0.0001378438,0.00001332204,0.000003449286,0.00001168006,0.00002932951,0.0004630742,0.9955108,0.0000583656,0.0003271011,0.003337918],"study_design_scores_gemma":[0.0002177266,0.0002726875,0.0001165169,0.00001798923,0.000003574927,0.000002050066,0.00007056529,0.0006591257,0.9903741,0.00003713458,0.007982832,0.0002456263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8740132,0.00008726292,0.124274,0.000599221,0.0004781616,0.0003594409,0.00001834365,0.0000250032,0.0001454326],"genre_scores_gemma":[0.9906915,0.00003520967,0.00745846,0.001499312,0.0001125581,0.00007485388,0.00002188018,0.00003472278,0.00007152234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1168155,"threshold_uncertainty_score":0.9330772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306243323811387,"score_gpt":0.2131784029865058,"score_spread":0.200115969748392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}