{"id":"W3024392979","doi":"10.1111/bcp.14355","title":"Novel strategies in immune checkpoint inhibitor drug development: How far are we from the paradigm shift?","year":2020,"lang":"en","type":"review","venue":"British Journal of Clinical Pharmacology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Drug development; Clinical trial; Immune system; Medicine; Biomarker; Milestone; Drug resistance; Drug; Immunotherapy; Immune checkpoint; Bioinformatics; Computational biology; Oncology; Pharmacology; Internal medicine; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004272472,0.000955796,0.001947209,0.00170103,0.0004536616,0.002870414,0.00178163,0.002687349,0.004820352],"category_scores_gemma":[0.003348686,0.0004577632,0.0008406114,0.001771335,0.002137175,0.007060495,0.001402683,0.007064953,0.003463422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001371308,"about_ca_system_score_gemma":0.002587376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086609,"about_ca_topic_score_gemma":0.002903956,"domain_scores_codex":[0.9991511,0.0002896388,0.00009032363,0.0001074308,0.0002811179,0.00008043209],"domain_scores_gemma":[0.9979047,0.001269212,0.0001700081,0.00006897598,0.0004203266,0.0001669108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001537116,0.0001482826,0.0001350394,0.01010711,0.00009008858,0.0001830052,0.0001519183,0.0007326571,0.001165509,0.03065272,0.05520556,0.9012744],"study_design_scores_gemma":[0.00008110837,0.0002559307,0.000303095,0.005295613,0.00006862885,0.0006152725,0.0001341025,0.0002610066,0.0003093393,0.01691029,0.9757347,0.00003082337],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009937797,0.9922647,0.0005247922,0.005429304,0.0005893561,0.000007272447,0.00001278458,0.00001438207,0.001058095],"genre_scores_gemma":[0.001010717,0.9941684,0.00103116,0.002354878,0.0007047937,0.00001622412,0.00001861072,0.000004477698,0.0006907018],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004820352,"threshold_uncertainty_score":0.02259529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1173383056139183,"score_gpt":0.4210594632119896,"score_spread":0.3037211575980713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}