{"id":"W3024410303","doi":"10.1089/hum.2020.078","title":"LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor β Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models","year":2020,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kellogg's (Canada)","funders":"National Cancer Institute","keywords":"Oncolytic virus; Cancer research; Immune system; Breast cancer; Immune checkpoint; Cancer; Growth factor; Medicine; Transforming growth factor; Oncolytic adenovirus; Immunotherapy; Immunology; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099802,0.0004001115,0.0002358786,0.0002583493,0.00009617787,0.000219669,0.0001826712,0.0002411509,0.0007135883],"category_scores_gemma":[0.0000536714,0.0001358686,0.0002117198,0.0001064309,0.0001683947,0.0001794077,0.0001022061,0.0006618662,0.0002144329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273783,"about_ca_system_score_gemma":0.0001956842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007829004,"about_ca_topic_score_gemma":0.001034621,"domain_scores_codex":[0.9999198,0.00001068835,0.000006258909,0.00001335719,0.00002757634,0.00002233455],"domain_scores_gemma":[0.999948,0.000006225896,0.00001878305,0.000007484718,0.000005744635,0.00001373529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272949,0.00005407106,0.00009590619,0.00002041445,0.000004627411,0.00001712122,0.000009526339,0.0001206311,0.9973515,0.0001332875,0.00003785833,0.002027653],"study_design_scores_gemma":[0.00004307904,0.0007516658,0.001073393,0.000004932731,0.000017382,0.0001584804,0.00001244353,0.001315287,0.9938318,0.000048223,0.002739255,0.000004024219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889375,0.002235364,0.006420114,0.0001464873,0.0000580914,0.00007824503,0.0003895123,0.0001680262,0.001566643],"genre_scores_gemma":[0.9868737,0.001957959,0.006327361,0.00004168289,0.00001407394,0.00006526495,0.0005144093,0.00002417211,0.004181318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007829004,"threshold_uncertainty_score":0.002387166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431642945955691,"score_gpt":0.2958732755778734,"score_spread":0.2527089809823043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}