{"id":"W3024410303","doi":"10.1089/hum.2020.078","title":"LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor β Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models","year":2020,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kellogg's (Canada)","funders":"National Cancer Institute","keywords":"Oncolytic virus; Cancer research; Immune system; Breast cancer; Immune checkpoint; Cancer; Growth factor; Medicine; Transforming growth factor; Oncolytic adenovirus; Immunotherapy; Immunology; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003584988,0.0005212451,0.0005399081,0.0001538834,0.0002531131,0.0001169458,0.0003044072,0.0001481678,0.00008082019],"category_scores_gemma":[0.00001345344,0.0004665966,0.0001479996,0.0002232317,0.0002151877,0.00004833119,0.0001171963,0.0003001776,0.000001619808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006312147,"about_ca_system_score_gemma":0.0001765233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004125701,"about_ca_topic_score_gemma":0.0001182718,"domain_scores_codex":[0.9972678,0.0002391774,0.0006190626,0.0008576021,0.0003710904,0.0006452161],"domain_scores_gemma":[0.9991241,0.00002520678,0.000161132,0.0002794907,0.0001177776,0.0002923367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004486327,0.0001929635,0.000871891,0.00006886004,0.0002023766,0.00001713072,0.001585836,0.0001503622,0.9890645,0.0000232248,0.00003243051,0.00330407],"study_design_scores_gemma":[0.005589738,0.002407367,0.0009649607,0.00003649314,0.00001212451,0.0000159153,0.0002132217,0.0002881237,0.9897231,0.000139996,0.00006351211,0.0005454719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790402,0.01858342,0.0001309248,0.0009027526,0.00003165341,0.0009936654,0.0002461244,0.00004716666,0.00002408035],"genre_scores_gemma":[0.9779115,0.01997338,0.0001409294,0.001197837,0.0003350161,0.0002134266,0.00008302767,0.0001238754,0.00002104538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002758598,"threshold_uncertainty_score":0.9997786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431642945955691,"score_gpt":0.2958732755778734,"score_spread":0.2527089809823043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}