{"id":"W3024455343","doi":"10.1101/2020.05.08.20092866","title":"Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Defence Science and Technology Laboratory; Hamilton Health Sciences Foundation; Parker Institute for Cancer Immunotherapy; Stanford Maternal and Child Health Research Institute; California Institute for Regenerative Medicine","keywords":"Cilium; Angiotensin-converting enzyme 2; Receptor; Respiratory tract; Motile cilium; Organelle; Biology; Renin–angiotensin system; Respiratory system; Cell biology; Subcellular localization; Airway; Angiotensin II; Angiotensin II receptor type 1; Internal medicine; Endocrinology; Medicine; Coronavirus disease 2019 (COVID-19); Biochemistry; Disease; Cytoplasm; Anesthesia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001125406,0.00048428,0.0007537006,0.0001545421,0.000178369,0.00006227121,0.0007555549,0.0004956319,0.00008136853],"category_scores_gemma":[0.002262534,0.0002556949,0.0002860972,0.0005635285,0.0003953666,0.00004762677,0.001210606,0.001352464,0.00005243305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001469556,"about_ca_system_score_gemma":0.0008748679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007230691,"about_ca_topic_score_gemma":0.00003371928,"domain_scores_codex":[0.9961422,0.0005797729,0.0006396753,0.0009600457,0.001217876,0.0004603927],"domain_scores_gemma":[0.9975181,0.0002691959,0.0003111153,0.001418435,0.0002890271,0.0001941622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001593962,0.000170083,0.03156371,0.0004850223,0.00008511853,0.00002635783,0.00109278,0.000003195411,0.8632978,0.000001016843,0.1005044,0.001176638],"study_design_scores_gemma":[0.000908669,0.0002583927,0.004857022,0.001216214,0.00006523479,0.000004271026,0.0001906916,0.0001559221,0.74593,0.000009635995,0.2461908,0.0002131104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689558,0.0009892228,0.00006969844,0.02620703,0.0002456691,0.003190484,0.0002291245,0.00007577334,0.00003720387],"genre_scores_gemma":[0.9597307,0.00002298093,0.0009152688,0.03804335,0.0005095294,0.0003614848,0.000008720047,0.0001207692,0.0002871443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1456864,"threshold_uncertainty_score":0.9999895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06059848217445696,"score_gpt":0.3090706518864952,"score_spread":0.2484721697120383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}