{"id":"W3024456898","doi":"10.1038/s41598-020-64460-z","title":"Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa; Occupational Cancer Research Centre","funders":"Fonds de Recherche du Québec - Santé; Terry Fox Research Institute; Deutsches Krebsforschungszentrum; Canada Research Chairs; McGill University","keywords":"Methotrexate; AMPK; Signal transduction; Pharmacology; Respiratory system; Medicine; Bioinformatics; Cancer research; Cell biology; Phosphorylation; Biology; Internal medicine; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148123,0.0003844097,0.0003595086,0.0003553143,0.0001519878,0.0003518298,0.0001518468,0.0004226942,0.00184515],"category_scores_gemma":[0.0001726227,0.0001568722,0.0003186445,0.0002604468,0.0002096961,0.0001592605,0.0001849294,0.0004938812,0.000381343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029884,"about_ca_system_score_gemma":0.0001911389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003966325,"about_ca_topic_score_gemma":0.001021097,"domain_scores_codex":[0.9997837,0.0000596756,0.00002713481,0.00004317524,0.00004606266,0.00004033112],"domain_scores_gemma":[0.9998516,0.0000344998,0.00005085032,0.00001809809,0.00001487008,0.0000300091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004865775,0.00003316525,0.0002776405,0.00006072551,0.000008689005,0.00005217522,0.000007733647,0.00004919437,0.9972038,0.0000392214,0.00004127746,0.00173976],"study_design_scores_gemma":[0.00004353542,0.0007647513,0.007140098,0.000009920463,0.00003269461,0.0002623502,0.00001974644,0.0002925587,0.98936,0.00003695797,0.002031965,0.00000547755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839336,0.00949978,0.002399507,0.0003703319,0.00008846289,0.00005308672,0.0009065003,0.0001323754,0.002616242],"genre_scores_gemma":[0.9925229,0.002811741,0.002220096,0.0001112633,0.00003604583,0.00003438798,0.0005650337,0.00001397524,0.001684583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184515,"threshold_uncertainty_score":0.006172657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306232732221936,"score_gpt":0.2494952376673154,"score_spread":0.236432910345096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}