{"id":"W3024459615","doi":"10.1073/pnas.1920433117","title":"Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Society of Fellows, Harvard University; March of Dimes Foundation; National Institutes of Health; Harvard University; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Japan Society for the Promotion of Science","keywords":"Tonotopy; Neuroscience; Auditory cortex; Biology; Neuroplasticity; Glutamatergic; Period (music); Glutamate receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003440552,0.00007705382,0.0001398025,0.00003485515,0.00009350173,0.00001512951,0.0003269216,0.0000922387,0.000003874798],"category_scores_gemma":[0.0008694218,0.0000583537,0.00006264073,0.0001653177,0.001023338,0.000022506,0.00006767407,0.00008479363,1.412056e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001011064,"about_ca_system_score_gemma":0.00004156648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000293521,"about_ca_topic_score_gemma":4.822807e-8,"domain_scores_codex":[0.9990107,0.000006703969,0.0002565986,0.0002127069,0.0004065405,0.000106742],"domain_scores_gemma":[0.9995369,0.00003490879,0.0001762573,0.000007173714,0.0001945245,0.00005024192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003132173,0.00002072581,0.001231351,0.0000966134,0.00001040356,6.843011e-9,0.0001698441,0.00001119716,0.9965844,0.00141194,0.0002742145,0.0001580059],"study_design_scores_gemma":[0.0001617696,0.0001879621,0.002749827,0.00003995102,0.00001277252,0.000004382616,0.0002729643,0.0003156583,0.9950423,0.0009563552,0.000184289,0.00007179032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966387,0.0002532836,0.000005222592,0.001884343,0.00002186441,0.00007239757,0.00002426541,0.000003883246,0.001096091],"genre_scores_gemma":[0.9980603,0.00004264803,0.001307449,0.0004100367,0.0001341409,0.000001475586,2.463912e-7,0.000004574128,0.00003914882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542098,"threshold_uncertainty_score":0.3770533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04987893163890111,"score_gpt":0.2800147293411249,"score_spread":0.2301357977022238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}