{"id":"W3024467615","doi":"10.1093/biolre/ioaa074","title":"Knockdown of IP3R1 disrupts tubulobulbar complex-ectoplasmic reticulum contact sites and the morphology of apical processes encapsulating late spermatids†","year":2020,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cell biology; Endoplasmic reticulum; Biology; Endosome; Sertoli cell; Cytoplasm; Small interfering RNA; Actin; Filopodia; Spermatogenesis; Intracellular; Cell culture; Endocrinology; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150729,0.0003187192,0.0002717418,0.0002994981,0.0001816341,0.0003193996,0.0003342929,0.000358118,0.002417233],"category_scores_gemma":[0.0001029413,0.0002053305,0.0002855612,0.0001851099,0.0003337974,0.0002347015,0.0002024018,0.0007757554,0.0005668935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004559639,"about_ca_system_score_gemma":0.0002945575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001889835,"about_ca_topic_score_gemma":0.002610766,"domain_scores_codex":[0.9998457,0.00001264933,0.0000205035,0.00004283369,0.00004088631,0.00003740778],"domain_scores_gemma":[0.9996787,0.00003586334,0.0001155844,0.00002093185,0.00002677258,0.0001220907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008990775,0.00001821026,0.0001825207,0.00003839325,0.000005580479,0.00005208282,0.00002249094,0.00005283745,0.9987327,0.0001134631,0.00006035867,0.0006313843],"study_design_scores_gemma":[0.00002196028,0.0001315145,0.0126084,0.000008394758,0.00002517586,0.0001486812,0.00008330451,0.001517588,0.9832986,0.00003966857,0.002109552,0.000007143881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911021,0.001007162,0.004724384,0.0001732001,0.00006058381,0.00003798059,0.001110213,0.0003024684,0.001481829],"genre_scores_gemma":[0.9920619,0.0004964767,0.001977722,0.00006187169,0.000009334344,0.00005232641,0.0005408779,0.00007765897,0.004721934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417233,"threshold_uncertainty_score":0.008086443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03144681314544594,"score_gpt":0.2682740085879616,"score_spread":0.2368271954425156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}