{"id":"W3024467615","doi":"10.1093/biolre/ioaa074","title":"Knockdown of IP3R1 disrupts tubulobulbar complex-ectoplasmic reticulum contact sites and the morphology of apical processes encapsulating late spermatids†","year":2020,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cell biology; Endoplasmic reticulum; Biology; Endosome; Sertoli cell; Cytoplasm; Small interfering RNA; Actin; Filopodia; Spermatogenesis; Intracellular; Cell culture; Endocrinology; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002653817,0.0001041997,0.000452368,0.00004448193,0.00003683148,0.000001692224,0.00004676526,0.00009795043,0.00008203319],"category_scores_gemma":[0.00285503,0.00006730309,0.00005784045,0.0001912016,0.0005767273,0.00004115673,0.00003923388,0.0001136053,0.000002398201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007313125,"about_ca_system_score_gemma":0.00003919983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000670685,"about_ca_topic_score_gemma":0.000002519971,"domain_scores_codex":[0.9989685,0.0001120117,0.0004179091,0.0003128477,0.00008303602,0.0001056847],"domain_scores_gemma":[0.9990182,0.0001746558,0.0003088336,0.0002288686,0.0002322712,0.00003716779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008695132,0.00007740589,0.1654214,0.0006153837,0.0001057615,0.000002449485,0.0008090629,0.00002207343,0.8295422,0.0008329779,0.0001395247,0.001562371],"study_design_scores_gemma":[0.004217667,0.002107751,0.4667792,0.0001367196,0.000379705,0.000566911,0.0004645076,0.002111474,0.5214322,0.0008944398,0.0007544493,0.0001549536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927812,0.001828992,0.0002897247,0.00447804,0.0001059449,0.0003525112,0.000008625376,0.00002558766,0.0001294064],"genre_scores_gemma":[0.9984611,0.0002312962,0.0009812474,0.00007742851,0.0001700588,0.000005940704,0.00005214157,0.000007567254,0.00001319494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.30811,"threshold_uncertainty_score":0.3417944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03144681314544594,"score_gpt":0.2682740085879616,"score_spread":0.2368271954425156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}