{"id":"W3024503379","doi":"10.1038/s41589-020-0528-7","title":"Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice","year":2020,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of General Medical Sciences; Oncode Institute; National Institute on Drug Abuse; European Federation of Pharmaceutical Industries and Associations; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; Innovative Medicines Initiative; European Commission; F. Hoffmann-La Roche; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit Leiden","keywords":"Anandamide; Fatty acid amide hydrolase; Endocannabinoid system; Cannabinoid receptor; Cannabinoid; Lipid signaling; Phospholipase D; Neuroprotection; Biology; Chemistry; Antagonist; Endocrinology; Neuroscience; Cell biology; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006865479,0.00011336,0.0003104597,0.00006469147,0.000009565038,0.000005238305,0.0001161549,0.000557525,0.00009547537],"category_scores_gemma":[0.0003028602,0.00008565901,0.000118665,0.0002260653,0.0001888347,0.00003780681,0.00009970273,0.0009050028,0.000006078395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005096014,"about_ca_system_score_gemma":0.00009955562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001783476,"about_ca_topic_score_gemma":0.000002543282,"domain_scores_codex":[0.9990768,0.00002612724,0.0001980052,0.0003010459,0.0001665383,0.0002314542],"domain_scores_gemma":[0.9996373,0.00002584986,0.00004227239,0.0001051043,0.0000774239,0.0001120458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003950176,0.0001639169,0.03646336,0.00008066696,0.00001408656,0.00002157262,0.00004345907,1.37461e-7,0.955319,0.0002920117,0.006351696,0.0008550409],"study_design_scores_gemma":[0.001227498,0.000264172,0.04029178,0.00004075109,0.0000203678,0.00003018736,0.00004223499,0.00004315856,0.9527174,0.0001052692,0.0051099,0.0001073449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788977,0.001156995,0.000004144854,0.01935363,0.0000881,0.0002170974,0.00006396093,0.00001519162,0.0002031688],"genre_scores_gemma":[0.9977916,0.00002967782,0.0001017934,0.001358236,0.0003061358,0.00002353472,0.0001701132,0.00001133392,0.0002075038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01889396,"threshold_uncertainty_score":0.4300143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615494224454144,"score_gpt":0.3023034913490603,"score_spread":0.2861485491045188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}