{"id":"W3024503379","doi":"10.1038/s41589-020-0528-7","title":"Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice","year":2020,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of General Medical Sciences; Oncode Institute; National Institute on Drug Abuse; European Federation of Pharmaceutical Industries and Associations; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; Innovative Medicines Initiative; European Commission; F. Hoffmann-La Roche; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit Leiden","keywords":"Anandamide; Fatty acid amide hydrolase; Endocannabinoid system; Cannabinoid receptor; Cannabinoid; Lipid signaling; Phospholipase D; Neuroprotection; Biology; Chemistry; Antagonist; Endocrinology; Neuroscience; Cell biology; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002507441,0.0006086859,0.0004252349,0.0004996308,0.0002545002,0.0004665578,0.000647614,0.0005299566,0.002350727],"category_scores_gemma":[0.0001791198,0.000312555,0.0005140258,0.0001893751,0.0004011084,0.000292398,0.0002217904,0.001387815,0.0006323641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005435427,"about_ca_system_score_gemma":0.0004936118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009880705,"about_ca_topic_score_gemma":0.002765257,"domain_scores_codex":[0.9998413,0.00001362083,0.0000127865,0.00003668485,0.00004638691,0.00004919515],"domain_scores_gemma":[0.9998657,0.00001913921,0.00003351456,0.00001126752,0.00001621604,0.0000542595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004138558,0.00008938585,0.0001621741,0.00005236833,0.00002776562,0.00009525243,0.00001025456,0.0001374762,0.9950843,0.0003885675,0.0002262609,0.003312245],"study_design_scores_gemma":[0.0002083424,0.0005741917,0.002189247,0.00002235738,0.00009111096,0.0003270891,0.00002222905,0.001186617,0.9851399,0.0001295037,0.01009693,0.00001242031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542128,0.005279557,0.02297729,0.001659416,0.0003312796,0.0003608692,0.004070698,0.0008232157,0.01028489],"genre_scores_gemma":[0.9642535,0.004735178,0.01628661,0.0005319562,0.00004893304,0.0002757469,0.002910301,0.000144352,0.01081343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002350727,"threshold_uncertainty_score":0.007863939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615494224454144,"score_gpt":0.3023034913490603,"score_spread":0.2861485491045188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}