{"id":"W3024512602","doi":"10.1021/acsomega.0c01282","title":"Development of Nanostructured Lipid Carriers for the Delivery of Idebenone in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero della Salute","keywords":"Idebenone; Coenzyme Q10; Chemistry; Oxidative stress; Lipid peroxidation; Pharmacology; Mitochondrial respiratory chain; Coenzyme Q – cytochrome c reductase; Biochemistry; Biophysics; Mitochondrion; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000882806,0.0001139925,0.0002391926,0.00002279256,0.00004101217,0.000002337106,0.0001933582,0.00007580928,0.000001917348],"category_scores_gemma":[0.000226102,0.00008540175,0.00006793274,0.000122921,0.00008534421,0.000002606538,0.0001565271,0.00004807894,2.877739e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008621334,"about_ca_system_score_gemma":0.0001101364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004124808,"about_ca_topic_score_gemma":0.0001908057,"domain_scores_codex":[0.9992301,0.00002102061,0.0002993359,0.0001846187,0.0001051694,0.0001596833],"domain_scores_gemma":[0.9994625,0.00005483937,0.0001786719,0.000161464,0.0001044635,0.00003799599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003663177,0.00001872608,0.001647511,0.0001958542,0.0001520915,6.097459e-7,0.001211097,0.0001161178,0.9900768,0.00001577198,0.00438584,0.001813289],"study_design_scores_gemma":[0.0008655645,0.0002977243,0.01119746,0.00004322877,0.00003437497,8.844303e-7,0.0005809899,0.0001083542,0.9774054,0.000005426678,0.009348661,0.0001119102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972844,0.001733577,0.0002601478,0.0002396527,0.0001182271,0.0002852617,0.00005562854,0.000002248451,0.00002082488],"genre_scores_gemma":[0.9989797,0.0001297415,0.0006185343,0.00009028733,0.00008279864,0.00002322818,0.00003212295,0.00001155201,0.00003197547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01267135,"threshold_uncertainty_score":0.3482582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233219498362377,"score_gpt":0.233028333549511,"score_spread":0.2206961385658872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}