{"id":"W3024533711","doi":"10.1039/d0cc02241a","title":"ArnD is a deformylase involved in polymyxin resistance","year":2020,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Polymyxin; Chemistry; Polymyxin B; Antibiotics; Lipid II; Microbiology; Biochemistry; Biology; Enzyme; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005232229,0.00007696238,0.0001760102,0.00004892293,0.00004677687,0.00001063755,0.000253,0.00006051397,0.0001710329],"category_scores_gemma":[0.0001722463,0.00007429993,0.00009464304,0.0005152768,0.0001271998,0.0000474117,0.0001379226,0.0002977678,0.0001131889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005748242,"about_ca_system_score_gemma":0.00005481808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001747409,"about_ca_topic_score_gemma":0.00005678221,"domain_scores_codex":[0.9993528,0.00002732213,0.0002427817,0.0001439279,0.0001101719,0.0001230037],"domain_scores_gemma":[0.9989107,0.00006570619,0.00004324913,0.0007432622,0.00005014182,0.0001869892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002220895,0.000784048,0.008151773,0.000162403,0.00007998542,0.00002232037,0.002865752,4.782514e-7,0.9404774,0.003076377,0.04300443,0.001152958],"study_design_scores_gemma":[0.00510221,0.00006455124,0.002118991,0.00111762,0.0001736909,0.000009495023,0.001926886,0.008919698,0.8307453,0.002403033,0.1468279,0.0005906136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7086294,0.001116089,0.000166935,0.2500947,0.000002879014,0.0002061868,0.00004080497,0.0001303885,0.03961258],"genre_scores_gemma":[0.9834998,0.00008653545,0.002772493,0.01303344,0.00002466004,0.00002610142,0.0001472646,0.000009162195,0.0004005437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2748703,"threshold_uncertainty_score":0.3029863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06475378869144102,"score_gpt":0.3113893074520802,"score_spread":0.2466355187606391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}