{"id":"W3024577926","doi":"10.1200/po.19.00335","title":"Multicenter Validation Study to Implement Plasma Epidermal Growth Factor Receptor T790M Testing in Clinical Laboratories","year":2020,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Mount Sinai Hospital; McGill University Health Centre; Lakeridge Health; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"T790M; Osimertinib; Concordance; Medicine; Epidermal growth factor receptor; Liquid biopsy; Internal medicine; Biopsy; Oncology; Cancer; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000399848,0.000155477,0.0004616049,0.00009876331,0.00006960161,0.00002173264,0.00009332328,0.00009179253,0.0003839692],"category_scores_gemma":[0.003482084,0.0001238803,0.00005411329,0.0004349681,0.00001891264,0.0001129239,0.0001265636,0.0002242169,0.0002084065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740306,"about_ca_system_score_gemma":0.0003928231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065474,"about_ca_topic_score_gemma":0.0001112634,"domain_scores_codex":[0.9978962,0.000316281,0.0008318381,0.0004586461,0.0002461024,0.0002509202],"domain_scores_gemma":[0.9980741,0.0009760073,0.0001607029,0.0001708766,0.0003182627,0.000300068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000956435,0.001958433,0.906101,0.0000181203,0.000102456,0.00007365191,0.006903477,0.00001908078,0.000794547,0.00002125773,0.004634223,0.07841734],"study_design_scores_gemma":[0.01294305,0.01299723,0.9143974,0.0000720793,0.0001950033,0.00000526324,0.004102066,0.0003725764,0.002230482,0.00001815294,0.05245001,0.00021674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878358,0.00001607982,0.0002303756,0.008711963,0.0006278202,0.001895111,0.00006342753,0.00006264757,0.0005568136],"genre_scores_gemma":[0.9865704,0.000009778035,0.01069468,0.002050645,0.0003659797,0.0001609887,0.00005445113,0.00002112232,0.00007198666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0782006,"threshold_uncertainty_score":0.5051692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092690041211498,"score_gpt":0.4780815492987679,"score_spread":0.3688125451776181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}