{"id":"W3024577926","doi":"10.1200/po.19.00335","title":"Multicenter Validation Study to Implement Plasma Epidermal Growth Factor Receptor T790M Testing in Clinical Laboratories","year":2020,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Mount Sinai Hospital; McGill University Health Centre; Lakeridge Health; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"T790M; Osimertinib; Concordance; Medicine; Epidermal growth factor receptor; Liquid biopsy; Internal medicine; Biopsy; Oncology; Cancer; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08027294,0.001584159,0.0007590139,0.0005661128,0.001537413,0.002110223,0.002994254,0.002126903,0.003124171],"category_scores_gemma":[0.06541714,0.000752623,0.001130704,0.000967667,0.001592196,0.001796464,0.002219224,0.002166454,0.001915574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004656635,"about_ca_system_score_gemma":0.01250483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008949772,"about_ca_topic_score_gemma":0.007035114,"domain_scores_codex":[0.9455733,0.04094142,0.002287045,0.003903719,0.005424127,0.001870476],"domain_scores_gemma":[0.928871,0.01216466,0.01344429,0.01452442,0.02450469,0.006491004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1120191,0.04196504,0.6805578,0.0006281289,0.001578145,0.0004006789,0.003151394,0.004755592,0.01867772,0.001927572,0.03374997,0.1005888],"study_design_scores_gemma":[0.06317582,0.1614796,0.6948764,0.0004252986,0.0009960348,0.001031843,0.001460925,0.01896778,0.0162644,0.001004267,0.04011854,0.000199166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9467593,0.0005483156,0.01310302,0.002199268,0.0003798738,0.02587757,0.003795108,0.0006945315,0.006643019],"genre_scores_gemma":[0.9519091,0.0001159775,0.02194257,0.001918997,0.0001912629,0.01725913,0.005531675,0.0001404605,0.0009908397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08027294,"threshold_uncertainty_score":0.424529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092690041211498,"score_gpt":0.4780815492987679,"score_spread":0.3688125451776181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}