{"id":"W3024579974","doi":"10.3390/cells9051238","title":"Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone","keywords":"Neurofilament; Zebrafish; RNA splicing; Alternative splicing; Biology; Gene isoform; Cell biology; Protein subunit; TARDBP; Axon; Amyotrophic lateral sclerosis; RNA-binding protein; Neuroscience; Messenger RNA; Gene; RNA; Genetics; SOD1; Mutant; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004362108,0.00004815579,0.000124257,0.00002838821,0.00001007216,0.000005810872,0.00002473665,0.00002842238,0.0001729197],"category_scores_gemma":[0.00001681132,0.0000413649,0.00001476868,0.0001237745,0.00001975283,0.00004068027,0.00003213697,0.00009051998,0.00001966638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001719969,"about_ca_system_score_gemma":0.00001826216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000779535,"about_ca_topic_score_gemma":3.797211e-7,"domain_scores_codex":[0.9994653,0.00001774127,0.000134199,0.0001349722,0.0001509023,0.00009685121],"domain_scores_gemma":[0.9997894,0.00001190908,0.00003170797,0.00006155415,0.00002690684,0.00007856922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008186137,0.00002512954,0.01327405,0.00007988853,0.000003788053,0.000008045237,0.0001781621,0.000003718161,0.9855013,0.00001207779,0.0001975086,0.0006344974],"study_design_scores_gemma":[0.0005339138,0.0001011426,0.6750993,0.00004975815,0.000003804622,0.000001637684,0.000006407513,0.0009879798,0.3223008,0.00000224237,0.0008819321,0.0000311396],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929626,0.000014958,0.00008733595,0.006446576,0.00003652313,0.0001631462,0.000002326593,0.000009245,0.0002772861],"genre_scores_gemma":[0.9985784,0.00004944253,0.00005036299,0.001009562,0.00008476595,0.000003647244,0.00001384164,0.000007356276,0.0002025755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6632005,"threshold_uncertainty_score":0.189335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671955024053536,"score_gpt":0.2352755946744072,"score_spread":0.2085560444338718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}