{"id":"W3024579974","doi":"10.3390/cells9051238","title":"Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone","keywords":"Neurofilament; Zebrafish; RNA splicing; Alternative splicing; Biology; Gene isoform; Cell biology; Protein subunit; TARDBP; Axon; Amyotrophic lateral sclerosis; RNA-binding protein; Neuroscience; Messenger RNA; Gene; RNA; Genetics; SOD1; Mutant; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475232,0.0002891223,0.0001572928,0.0004781206,0.0002380614,0.0001850843,0.0002300244,0.0003828824,0.001547169],"category_scores_gemma":[0.0001753949,0.0002229818,0.0003210886,0.0001068306,0.0003115875,0.0002211056,0.0002386104,0.0004692146,0.0005496166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005508014,"about_ca_system_score_gemma":0.0002803815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005104718,"about_ca_topic_score_gemma":0.00623861,"domain_scores_codex":[0.9998993,0.000005064147,0.0000102198,0.00003223055,0.00003384917,0.00001929391],"domain_scores_gemma":[0.9998298,0.00002440321,0.00005846778,0.00001423204,0.0000341064,0.00003889746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001556662,0.000003791909,0.0001621635,0.000009831289,0.000001445588,0.00006226421,0.0000153271,0.00002583113,0.9992148,0.0000748153,0.0000104499,0.0004036978],"study_design_scores_gemma":[0.00001916552,0.000202578,0.02209857,0.00001496365,0.00003303298,0.0008591592,0.00009319954,0.001459816,0.9713696,0.0001524686,0.003679393,0.00001794692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870154,0.0005450179,0.008864925,0.0001377202,0.00003193898,0.00004669765,0.001151312,0.0001225975,0.002084548],"genre_scores_gemma":[0.9766099,0.0007015959,0.008944716,0.00009819208,0.000006426419,0.0001004154,0.001508725,0.000124296,0.01190579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005104718,"threshold_uncertainty_score":0.01015002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671955024053536,"score_gpt":0.2352755946744072,"score_spread":0.2085560444338718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}