{"id":"W3024633008","doi":"10.1534/genetics.120.303169","title":"A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in <i>Caenorhabditis elegans</i>","year":2020,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institutes of Health","keywords":"Biology; Genetics; Caenorhabditis elegans; Pharmacogenetics; DNA repair; DNA damage; Genotype; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221859,0.000328433,0.0002353978,0.0003386353,0.000185442,0.0001764103,0.0002056385,0.0002588678,0.0006746028],"category_scores_gemma":[0.00009549638,0.0001225721,0.0003041925,0.0001163264,0.000176975,0.0001040649,0.0001148867,0.0003436089,0.00012531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005474845,"about_ca_system_score_gemma":0.0003121964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002361983,"about_ca_topic_score_gemma":0.003655945,"domain_scores_codex":[0.9998944,0.0000109255,0.00001018482,0.00003219519,0.00003406293,0.00001828816],"domain_scores_gemma":[0.9999154,0.000009788087,0.00003653453,0.000009073833,0.00001510329,0.00001409722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002919951,0.00001482858,0.0001313867,0.00001148078,0.000002440372,0.00001253559,0.000001944393,0.000147608,0.9989305,0.00002885283,0.00001713289,0.0006721144],"study_design_scores_gemma":[0.00001137022,0.0004601203,0.004913415,0.000004975188,0.00002064961,0.0001052178,0.00001100349,0.002165789,0.9912919,0.00002849722,0.0009808376,0.00000615761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931169,0.0003220433,0.004382925,0.00007709987,0.00001510106,0.00009578694,0.0009357072,0.000141153,0.0009132078],"genre_scores_gemma":[0.9898977,0.0004314139,0.00681459,0.00006719299,0.000004725726,0.0001283304,0.0007341657,0.00003897394,0.00188288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361983,"threshold_uncertainty_score":0.004696429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007338079762850943,"score_gpt":0.2331414654180329,"score_spread":0.2258033856551819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}