{"id":"W3024644439","doi":"10.1016/j.virusres.2020.198015","title":"The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection","year":2020,"lang":"en","type":"review","venue":"Virus Research","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Ubiquitin ligase; Lytic cycle; Ubiquitin; Proteome; Herpes simplex virus; Viral replication; Cell biology; Ubiquitin-Protein Ligases; Virus; Virology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256784,0.0005451649,0.0007115195,0.001488549,0.0001732394,0.0007497804,0.0004431118,0.0005317579,0.004215182],"category_scores_gemma":[0.0003449818,0.000176363,0.000354746,0.001280037,0.0002013062,0.0007347423,0.0004763926,0.0008829899,0.002531198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004384224,"about_ca_system_score_gemma":0.00064402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006965541,"about_ca_topic_score_gemma":0.001020682,"domain_scores_codex":[0.9999145,0.00001217344,0.00001227759,0.00001356162,0.0000362698,0.00001116828],"domain_scores_gemma":[0.9999119,0.00003000396,0.00001457962,0.000002818454,0.00002913541,0.00001160575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008159447,0.00005165781,0.0001165374,0.01590176,0.00006743582,0.0001291425,0.00004061875,0.0002620745,0.004022236,0.002743204,0.01995739,0.9566264],"study_design_scores_gemma":[0.000009352545,0.00006949449,0.0004689277,0.001806071,0.00006464928,0.000668894,0.00003164336,0.00005472954,0.001043858,0.0009351965,0.9948375,0.000009724079],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003180045,0.9969519,0.0001687887,0.0001972657,0.0002173922,0.00000697537,0.00004408229,0.00001294798,0.002082529],"genre_scores_gemma":[0.0009375859,0.9978268,0.0001423084,0.00008718259,0.00006784375,0.000005315383,0.00004865064,0.000001582514,0.0008827983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004215182,"threshold_uncertainty_score":0.01410121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2521745342331191,"score_gpt":0.488200984917066,"score_spread":0.2360264506839468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}