{"id":"W3024684302","doi":"10.1158/2159-8290.cd-19-1390","title":"The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; Jewish General Hospital; Institute of Cancer Research","funders":"National Cancer Institute; Susan G. Komen; American Association for Cancer Research; U.S. Department of Defense","keywords":"Cancer research; Breast cancer; KRAS; AKT1; Cancer; Metastatic breast cancer; Cyclin-dependent kinase 4; CHEK1; Kinase; Biology; Estrogen receptor; Cyclin-dependent kinase 6; Medicine; Internal medicine; Cell cycle; Cyclin-dependent kinase; Cell cycle checkpoint; Signal transduction; PI3K/AKT/mTOR pathway; Cyclin-dependent kinase 2; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460541,0.0001138784,0.000190223,0.0004705153,0.0001846458,0.0003450622,0.0001283548,0.000261735,0.00203251],"category_scores_gemma":[0.0006923269,0.00009089094,0.0001247644,0.0004560569,0.0001834026,0.0001718135,0.0001861072,0.0002512941,0.0001841027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597783,"about_ca_system_score_gemma":0.00008995135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005692328,"about_ca_topic_score_gemma":0.0007107699,"domain_scores_codex":[0.999853,0.00002744992,0.000010693,0.00005083439,0.0000268472,0.00003114755],"domain_scores_gemma":[0.9997247,0.0000805317,0.0001051929,0.00002063473,0.00002641312,0.00004240017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006710091,0.00002967814,0.9720783,0.00001850404,0.00006045097,0.0006878072,0.00008142422,0.0002247031,0.01667661,0.000107919,0.0002696352,0.009093856],"study_design_scores_gemma":[0.00001001701,0.0001320545,0.9951734,0.000004068987,0.00003547986,0.002039597,0.000113171,0.0004902052,0.001308796,0.0001379252,0.000551362,0.000003825607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990252,0.0001952906,0.00008355768,0.00006151317,0.000001731517,0.00000309716,0.0002180696,0.000004887586,0.0004065624],"genre_scores_gemma":[0.9997091,0.00004037598,0.00004616503,0.00001633384,0.000003821192,0.000001828518,0.0001155768,0.000001617906,0.00006523756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203251,"threshold_uncertainty_score":0.006799459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007344171976413173,"score_gpt":0.2373030143662544,"score_spread":0.2299588423898413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}