{"id":"W3024684302","doi":"10.1158/2159-8290.cd-19-1390","title":"The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; Jewish General Hospital; Institute of Cancer Research","funders":"National Cancer Institute; Susan G. Komen; American Association for Cancer Research; U.S. Department of Defense","keywords":"Cancer research; Breast cancer; KRAS; AKT1; Cancer; Metastatic breast cancer; Cyclin-dependent kinase 4; CHEK1; Kinase; Biology; Estrogen receptor; Cyclin-dependent kinase 6; Medicine; Internal medicine; Cell cycle; Cyclin-dependent kinase; Cell cycle checkpoint; Signal transduction; PI3K/AKT/mTOR pathway; Cyclin-dependent kinase 2; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008748005,0.000257125,0.0004799792,0.00007493191,0.00007662762,0.00003636763,0.000132461,0.00003769357,0.00002377427],"category_scores_gemma":[0.00002726606,0.0001741142,0.00004850549,0.0004282435,0.0001928748,0.0002920528,0.00009580595,0.0001483926,0.000002744822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003723295,"about_ca_system_score_gemma":0.0002796442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002105172,"about_ca_topic_score_gemma":0.0006537883,"domain_scores_codex":[0.9984089,0.00005672083,0.0003773775,0.0004550187,0.0003660433,0.0003359914],"domain_scores_gemma":[0.9990959,0.0000839889,0.0002099365,0.0002580452,0.0001495941,0.0002025877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06960879,0.0004097669,0.756654,0.0005088196,0.0009771134,0.00004664923,0.006766419,0.0009471795,0.03515172,0.0001375072,0.001320492,0.1274716],"study_design_scores_gemma":[0.006588249,0.0004376443,0.9853914,0.0006679444,0.0001558163,0.000002297294,0.0009065524,0.000007460707,0.004499393,0.00003161699,0.001021821,0.0002897387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796846,0.01323265,0.00008085025,0.005135528,0.0001349518,0.0009350092,0.0007347307,0.00001979101,0.00004191355],"genre_scores_gemma":[0.9970879,0.001155835,0.0001712114,0.0009760549,0.0001805788,0.0002195237,0.00002200713,0.00005121604,0.0001356793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2287375,"threshold_uncertainty_score":0.7100171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007344171976413173,"score_gpt":0.2373030143662544,"score_spread":0.2299588423898413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}