{"id":"W3024802608","doi":"10.1016/j.chembiol.2020.04.005","title":"Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Virulence; Salmonella; Polymyxin; Microbiology; Biology; Colistin; Antibiotics; Antibiotic resistance; Pathogen; Gene; Bacteria; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223423,0.0004912972,0.0003171046,0.0003011907,0.0002410562,0.00066578,0.0004572063,0.0004556214,0.001723382],"category_scores_gemma":[0.0001963992,0.0002489796,0.0002739765,0.0001486632,0.0002977946,0.0002152534,0.0002839064,0.0008209305,0.0004418645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000734709,"about_ca_system_score_gemma":0.0004131085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005762972,"about_ca_topic_score_gemma":0.001430954,"domain_scores_codex":[0.9998739,0.00001530247,0.000005785381,0.00002111344,0.00004139338,0.00004246963],"domain_scores_gemma":[0.9999224,0.00002008081,0.00001563624,0.00000791714,0.00001167398,0.00002232014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001180094,0.00007061553,0.0001019175,0.00003965927,0.000009846867,0.00003692725,0.00001015996,0.000343454,0.995159,0.0005863656,0.0001437422,0.003380382],"study_design_scores_gemma":[0.00005476927,0.0004726538,0.0009364751,0.000005738717,0.00002413946,0.00009706887,0.00001441921,0.003931503,0.9889235,0.0001759939,0.005355192,0.000008486063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580958,0.004319361,0.02782068,0.0009513866,0.0002096029,0.0002270778,0.0003654821,0.000858456,0.007152197],"genre_scores_gemma":[0.9895579,0.001511881,0.004253807,0.0001850074,0.00002137327,0.00006232836,0.0002282564,0.00003197856,0.00414755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723382,"threshold_uncertainty_score":0.005765259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025030299060991,"score_gpt":0.2214559241058217,"score_spread":0.1964256250448307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}